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Type: Journal article
Title: From crescent to mature virion: vaccinia virus assembly and maturation
Author: Liu, L.
Cooper, T.
Howley, P.
Hayball, J.
Citation: Viruses, 2014; 6(10):3787-3808
Publisher: MDPI AG
Issue Date: 2014
ISSN: 1999-4915
Statement of
Liang Liu, Tamara Cooper, Paul M. Howley, and John D. Hayball
Abstract: Vaccinia virus (VACV) has achieved unprecedented success as a live viral vaccine for smallpox which mitigated eradication of the disease. Vaccinia virus has a complex virion morphology and recent advances have been made to answer some of the key outstanding questions, in particular, the origin and biogenesis of the virion membrane, the transformation from immature virion (IV) to mature virus (MV), and the role of several novel genes, which were previously uncharacterized, but have now been shown to be essential for VACV virion formation. This new knowledge will undoubtedly contribute to the rational design of safe, immunogenic vaccine candidates, or effective antivirals in the future. This review endeavors to provide an update on our current knowledge of the VACV maturation processes with a specific focus on the initiation of VACV replication through to the formation of mature virions.
Keywords: vaccinia virus; virus assembly; membrane biogenesis; virion formation
Description: Review
Rights: © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (
DOI: 10.3390/v6103787
Appears in Collections:Aurora harvest 3
Medicine publications

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