Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
Full metadata record
|dc.identifier.citation||Journal of Clinical Endocrinology and Metabolism, 2004; 89(4):1646-1649||en|
|dc.description||Copyright © 2004 by The Endocrine Society||en|
|dc.description.abstract||It has been known for many years that serum PTH rises with age, and it has been suggested that this rise may contribute to bone loss in postmenopausal women. It has been variously attributed to declining renal function, declining calcium absorption efficiency, and declining serum 25-hydroxyvitamin D [25(OH)D] levels. We studied the effects of age, weight, renal function, radiocalcium absorption, serum ionized calcium, and serum 25(OH)D on serum PTH levels in 918 postmenopausal women attending an osteoporosis center. On simple linear regression, serum PTH was a positive function of age (P = 0.003) and weight (P < 0.001) and an inverse function of serum 25(OH)D (P < 0.001) and serum ionized calcium (P = 0.002). On stepwise regression, serum 25(OH)D was the most significant (negative) determinant of serum PTH, followed in decreasing order of significance by serum ionized calcium (negative) and body weight and age (positive). Serum PTH was not related to radiocalcium absorption. The reciprocal relation between serum PTH and serum 25(OH)D could not be explained by the serum concentration of 1,25-dihydroxyvitamin D, which did not change with age. After adjustment for serum ionized calcium, body weight, and age, the rise in serum PTH appeared to start when serum 25(OH)D fell less than 80 nmol/liter.||en|
|dc.description.statementofresponsibility||Allan G. Need, Peter D. O’Loughlin, Howard A. Morris, Michael Horowitz, and B. E. Christopher Nordin||en|
|dc.subject||Humans; Parathyroid Hormone; Vitamin D; Aging; Postmenopause; Aged; Middle Aged; Female||en|
|dc.title||The effects of age and other variables on serum parathyroid hormone in postmenopausal women attending an osteoporosis center||en|
|dc.identifier.orcid||Morris, H. [0000-0002-2745-3750]||en|
|dc.identifier.orcid||Horowitz, M. [0000-0002-0942-0306]||en|
|Appears in Collections:||Medicine publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.