Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/9588
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dc.contributor.authorNeed, A.en
dc.contributor.authorO'Loughlin, P.en
dc.contributor.authorMorris, H.en
dc.contributor.authorHorowitz, M.en
dc.contributor.authorNordin, B.en
dc.date.issued2004en
dc.identifier.citationJournal of Clinical Endocrinology and Metabolism, 2004; 89(4):1646-1649en
dc.identifier.issn0021-972Xen
dc.identifier.issn1945-7197en
dc.identifier.urihttp://hdl.handle.net/2440/9588-
dc.descriptionCopyright © 2004 by The Endocrine Societyen
dc.description.abstractIt has been known for many years that serum PTH rises with age, and it has been suggested that this rise may contribute to bone loss in postmenopausal women. It has been variously attributed to declining renal function, declining calcium absorption efficiency, and declining serum 25-hydroxyvitamin D [25(OH)D] levels. We studied the effects of age, weight, renal function, radiocalcium absorption, serum ionized calcium, and serum 25(OH)D on serum PTH levels in 918 postmenopausal women attending an osteoporosis center. On simple linear regression, serum PTH was a positive function of age (P = 0.003) and weight (P < 0.001) and an inverse function of serum 25(OH)D (P < 0.001) and serum ionized calcium (P = 0.002). On stepwise regression, serum 25(OH)D was the most significant (negative) determinant of serum PTH, followed in decreasing order of significance by serum ionized calcium (negative) and body weight and age (positive). Serum PTH was not related to radiocalcium absorption. The reciprocal relation between serum PTH and serum 25(OH)D could not be explained by the serum concentration of 1,25-dihydroxyvitamin D, which did not change with age. After adjustment for serum ionized calcium, body weight, and age, the rise in serum PTH appeared to start when serum 25(OH)D fell less than 80 nmol/liter.en
dc.description.statementofresponsibilityAllan G. Need, Peter D. O’Loughlin, Howard A. Morris, Michael Horowitz, and B. E. Christopher Nordinen
dc.language.isoenen
dc.publisherEndocrine Societyen
dc.subjectHumans; Parathyroid Hormone; Vitamin D; Aging; Postmenopause; Aged; Middle Aged; Femaleen
dc.titleThe effects of age and other variables on serum parathyroid hormone in postmenopausal women attending an osteoporosis centeren
dc.typeJournal articleen
dc.identifier.rmid0020040315en
dc.identifier.doi10.1210/jc.2003-031539en
dc.identifier.pubid57128-
pubs.library.collectionMedicine publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidMorris, H. [0000-0002-2745-3750]en
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]en
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