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Type: Journal article
Title: How to use: The direct antiglobulin test in newborns
Author: Keir, A.
Agpalo, M.
Lieberman, L.
Callum, J.
Citation: Archives of Disease in Childhood: Education and Practice Edition, 2015; 100(4):198-203
Publisher: BMJ Publishing
Issue Date: 2015
ISSN: 1743-0585
Statement of
Amy Keir, Minda Agpalo, Lani Lieberman, Jeannie Callum
Abstract: The direct antiglobulin test (DAT) detects the presence of immunoglobulin, complement or both bound to the red blood cell membrane. The test, historically called the ‘ Coombs test ’ , was first described in 1945 by Cambridge immunologist Robin Coombs. Suspected haemolytic disease of the newborn, due to either Rhesus disease or ABO incompatibility, is one of most common reasons for requesting a DAT in newborns. In this article, we discuss the physiological background and technological background of the DAT. We also provide a clinical framework for a rational approach to the use and interpretation of the DAT in newborns.
Keywords: Humans
Erythroblastosis, Fetal
Blood Group Incompatibility
ABO Blood-Group System
Infant, Newborn
Coombs Test
Rights: © 2015 BMJ Publishing Group Ltd & Royal College of Paediatrics and Child Health. All rights reserved.
DOI: 10.1136/archdischild-2013-305553
Appears in Collections:Aurora harvest 7
Paediatrics publications

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