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Type: Journal article
Title: Comparative genomics of the mimicry switch in Papilio dardanus
Author: Timmermans, M.
Baxter, S.
Clark, R.
Heckel, D.
Vogel, H.
Collins, S.
Papanicolaou, A.
Fukova, I.
Joron, M.
Thompson, M.
Jiggins, C.
ffrench-Constant, R.
Vogler, A.
Citation: Proceedings of the Royal Society B: Biological Sciences, 2014; 281(1787):1-8
Publisher: The Royal Society
Issue Date: 2014
ISSN: 0962-8452
Statement of
Martijn J. T. N. Timmermans, Simon W. Baxter, Rebecca Clark, David G. Heckel, Heiko Vogel, Steve Collins, Alexie Papanicolaou, Iva Fukova, Mathieu Joron, Martin J. Thompson, Chris D. Jiggins, Richard H. ffrench-Constant and Alfried P. Vogler
Abstract: The African Mocker Swallowtail, Papilio dardanus, is a textbook example in evolutionary genetics. Classical breeding experiments have shown that wing pattern variation in this polymorphic Batesian mimic is determined by the polyallelic H locus that controls a set of distinct mimetic phenotypes. Using bacterial artificial chromosome (BAC) sequencing, recombination analyses and comparative genomics,we showthatHco-segregateswith an interval of less than 500 kb that is collinear with two other Lepidoptera genomes and contains 24 genes, including the transcription factor genes engrailed (en) and invected (inv). H is located in a region of conserved gene order, which argues against any role for genomic translocations in the evolution of a hypothesizedmulti-gene mimicry locus. Natural populations of P. dardanus show significant associations of specific morphs with single nucleotide polymorphisms (SNPs), centred on en. In addition, SNP variation in the H region reveals evidence of non-neutral molecular evolution in the en gene alone. We find evidence for a duplication potentially driving physical constraints on recombination in the lamborni morph. Absence of perfect linkage disequilibrium between different genes in the other morphs suggests that H is limited to nucleotide positions in the regulatory and coding regions of en. Our results therefore support the hypothesis that a single gene underlies wing pattern variation in P. dardanus.
Keywords: Batesian mimicry; polymorphism; Lepidoptera; supergene; genotype–phenotype associations
Rights: © 2014 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License, which permits unrestricted use, provided the original author and source are credited.
DOI: 10.1098/rspb.2014.0465
Appears in Collections:Aurora harvest 3
Molecular and Biomedical Science publications

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