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|Title:||The timing between REM sleep behavior disorder and Parkinson's disease|
|Citation:||Sleep and Breathing, 2014; 18(2):319-323|
|Raffaele Ferri, Filomena I. I. Cosentino, Fabio Pizza, Debora Aricò, Giuseppe Plazzi|
|Abstract:||PURPOSE: In Parkinson's disease (PD) patients, REM sleep behavior disorder (RBD) might precede PD or develop with or after the onset of PD. No previous study has explored differences between these two groups. The aim of this study was therefore to compare clinical features and REM sleep chin electromyographic patterns between patients in whom RBD heralded PD and those in whom RBD occurrence coincided with or followed the clinical manifestations of PD. METHOD: Twenty-seven consecutive PD patients (mean age 67.9 years) were enrolled. Detailed clinical, laboratory, and polysomnographic studies were obtained in all participants. RESULTS: Sixteen of the 27 patients were affected by RBD. These had a significantly higher stage of PD and took significantly higher doses of dopaminergic therapy; their disease duration tended to be longer, and their cognitive status tended to be lower. PD patients in whom RBD preceded PD (n = 6) did not differ from PD patients without RBD in disease parameters, while PD patients in whom RBD developed with or after PD (n = 10) showed a significantly higher disease stage, took significantly higher dopaminergic therapy, and had a longer disease duration. CONCLUSION: Our findings are compatible with the hypothesis that patients in whom RBD precedes, or does not precede, PD might constitute two possibly distinct clinical and physiopathological groups, based on different progressive neuropathological sequences of events.|
|Keywords:||REM sleep behavior disorder; Parkinson’s disease; Synucleinopathies; Neurodegenerative disorders; Sleep disorders; Parasomnia|
|Description:||There is an erratum to this article: The affiliation should have been noted as follows for Drs. Plazzi and Pizza: Department of Biomedical and Neuromotor Sciences, University of Bologna and IRCCS Institute of Neurological Sciences, Bologna, Italy|
|Rights:||© Springer-Verlag Berlin Heidelberg 2013|
|Appears in Collections:||Medicine publications|
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