Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/95930
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: The timing between REM sleep behavior disorder and Parkinson's disease
Author: Ferri, R.
Cosentino, F.
Pizza, F.
Aricò, D.
Plazzi, G.
Citation: Sleep and Breathing, 2014; 18(2):319-323
Publisher: Springer
Issue Date: 2014
ISSN: 1520-9512
1522-1709
Statement of
Responsibility: 
Raffaele Ferri, Filomena I. I. Cosentino, Fabio Pizza, Debora Aricò, Giuseppe Plazzi
Abstract: PURPOSE: In Parkinson's disease (PD) patients, REM sleep behavior disorder (RBD) might precede PD or develop with or after the onset of PD. No previous study has explored differences between these two groups. The aim of this study was therefore to compare clinical features and REM sleep chin electromyographic patterns between patients in whom RBD heralded PD and those in whom RBD occurrence coincided with or followed the clinical manifestations of PD. METHOD: Twenty-seven consecutive PD patients (mean age 67.9 years) were enrolled. Detailed clinical, laboratory, and polysomnographic studies were obtained in all participants. RESULTS: Sixteen of the 27 patients were affected by RBD. These had a significantly higher stage of PD and took significantly higher doses of dopaminergic therapy; their disease duration tended to be longer, and their cognitive status tended to be lower. PD patients in whom RBD preceded PD (n = 6) did not differ from PD patients without RBD in disease parameters, while PD patients in whom RBD developed with or after PD (n = 10) showed a significantly higher disease stage, took significantly higher dopaminergic therapy, and had a longer disease duration. CONCLUSION: Our findings are compatible with the hypothesis that patients in whom RBD precedes, or does not precede, PD might constitute two possibly distinct clinical and physiopathological groups, based on different progressive neuropathological sequences of events.
Keywords: REM sleep behavior disorder; Parkinson’s disease; Synucleinopathies; Neurodegenerative disorders; Sleep disorders; Parasomnia
Description: There is an erratum to this article: The affiliation should have been noted as follows for Drs. Plazzi and Pizza: Department of Biomedical and Neuromotor Sciences, University of Bologna and IRCCS Institute of Neurological Sciences, Bologna, Italy
Rights: © Springer-Verlag Berlin Heidelberg 2013
RMID: 0030037398
DOI: 10.1007/s11325-013-0887-3
Appears in Collections:Medicine publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.