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Type: Journal article
Title: The role of gastrointestinal vagal afferent fibres in obesity
Author: Kentish, S.
Page, A.
Citation: Journal of Physiology, 2015; 593(4):775-786
Publisher: Wiley
Issue Date: 2015
ISSN: 0022-3751
Statement of
Stephen J. Kentish and Amanda J. Page
Abstract: Gastrointestinal (GI) vagal afferents are a key mediatory of food intake. Through a balance of responses to chemical and mechanical stimuli food intake can be tightly controlled via the ascending satiety signals initiated in the GI tract. However, vagal responses to both mechanical and chemical stimuli are modified in diet-induced obesity (DIO). Much of the research to date whilst in relatively isolated/controlled circumstances indicates a shift between a balance of orexigenic and anorexigenic vagal signals to blunted anorexigenic and potentiated orexigenic capacity. Although the mechanism responsible for the DIO shift in GI vagal afferent signalling is unknown, one possible contributing factor is the gut microbiota. Nevertheless, whatever the mechanism, the observed changes in gastrointestinal vagal afferent signalling may underlie the pathophysiological changes in food consumption that are pivotal for the development and maintenance of obesity.
Keywords: Gastrointestinal Tract; Neurons, Afferent; Vagus Nerve; Animals; Humans; Obesity; Gastrointestinal Microbiome
Description: Topical Review
Rights: © 2014 The Authors. The Journal of Physiology © 2014 The Physiological Society
RMID: 0030016573
DOI: 10.1113/jphysiol.2014.278226
Appears in Collections:Medicine publications

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