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Type: Journal article
Title: Splice factor mutations and alternative splicing as drivers of hematopoietic malignancy
Author: Hahn, C.
Venugopal, P.
Scott, H.
Hiwase, D.
Citation: Immunological Reviews, 2015; 263(1):257-278
Publisher: Wiley
Issue Date: 2015
ISSN: 0105-2896
Statement of
Christopher N. Hahn, Parvathy Venugopal, Hamish S. Scott, Devendra K. Hiwase
Abstract: Differential splicing contributes to the vast complexity of mRNA transcripts and protein isoforms that are necessary for cellular homeostasis and response to developmental cues and external signals. The hematopoietic system provides an exquisite example of this. Recently, discovery of mutations in components of the spliceosome in various hematopoietic malignancies (HMs) has led to an explosion in knowledge of the role of splicing and splice factors in HMs and other cancers. A better understanding of the mechanisms by which alternative splicing and aberrant splicing contributes to the leukemogenic process will enable more efficacious targeted approaches to tackle these often difficult to treat diseases. The clinical implications are only just starting to be realized with novel drug targets and therapeutic strategies open to exploitation for patient benefit.
Keywords: alternative splicing; splice factors; leukemogenesis; hematopoietic malignancy; hematopoiesis
Description: Article first published online: 15 DEC 2014
Rights: © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
DOI: 10.1111/imr.12241
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