Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/96112
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dc.contributor.authorJain, N.en
dc.contributor.authorIto, S.en
dc.contributor.authorTian, X.en
dc.contributor.authorKurlander, R.en
dc.contributor.authorBattiwalla, M.en
dc.contributor.authorLu, K.en
dc.contributor.authorSavani, B.en
dc.contributor.authorMalkovska, V.en
dc.contributor.authorRezvani, K.en
dc.contributor.authorLe, R.en
dc.contributor.authorShenoy, A.en
dc.contributor.authorHourigan, C.en
dc.contributor.authorKeyvanfar, K.en
dc.contributor.authorKoklanaris, E.en
dc.contributor.authorSuperata, J.en
dc.contributor.authorMuranski, P.en
dc.contributor.authorBarrett, A.en
dc.contributor.authorYong, A.en
dc.date.issued2014en
dc.identifier.citationBone Marrow Transplantation, 2014; 50(2):189-196en
dc.identifier.issn0268-3369en
dc.identifier.issn1476-5365en
dc.identifier.urihttp://hdl.handle.net/2440/96112-
dc.description.abstractAlthough there are now fewer allo-SCTs performed for CML, leukemic relapse post transplant remains a persistent problem. To better define clinical and biological parameters determining postrelapse outcome, we studied 59 patients with CML relapsing after HLA-identical sibling allo-SCT between 1993 and 2008. Eighteen (30.5%) were transplanted in advanced phase and 41 (69.5%) in chronic phase. With a median follow-up from relapse of 7.9 years, 5-year post relapse survival (PRS) was 62%. Multivariate analysis found disease status at transplant, time to diagnosis of relapse from transplant and pretransplant tyrosine kinase inhibitor (TKI) use as significant factors associated with PRS. Analysis of BCR-ABL transcript expression in the hematopoietic progenitor compartment was performed in 36 patients (22 relapsed, 8 non-relapsed and 6 TKI alone controls). Patients with BCR-ABL expression in their early hematopoietic stem cell compartment (Lineage−CD34+CD38−CD90+) had worse survival irrespective of the disease status. We conclude that disease status remains the strongest clinical prognostic factor for PRS in CML following allo-SCT. The persistence of BCR-ABL expression in the progenitor cell compartment in some patients after SCT emphasizes the need to target CML-leukemia stem cells.en
dc.description.statementofresponsibilityNA Jain, S Ito, X Tian, R Kurlander, M Battiwalla, K Lu, BN Savani, V Malkovska, K Rezvani, RQ Le, A Shenoy, CS Hourigan, K Keyvanfar, E Koklanaris, J Superata, P Muranski, AJ Barrett, and ASM Yongen
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.rights© 2015 Macmillan Publishers Limited All rights reserveden
dc.subjectHumans; Recurrence; Disease-Free Survival; Hematopoietic Stem Cell Transplantation; Survival Rate; Retrospective Studies; Follow-Up Studies; Adult; Middle Aged; Female; Male; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Allograftsen
dc.titleClinical and biological predictors of outcome following relapse of CML post-allo-SCTen
dc.typeJournal articleen
dc.identifier.rmid0030021378en
dc.identifier.doi10.1038/bmt.2014.249en
dc.identifier.pubid170731-
pubs.library.collectionMedicine publicationsen
pubs.library.teamDS07en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidYong, A. [0000-0001-9452-1533]en
Appears in Collections:Medicine publications

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