Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/96236
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dc.contributor.authorLeach, R.en
dc.contributor.authorO'Neill, R.en
dc.contributor.authorFitzpatrick, J.en
dc.contributor.authorWilliams, J.en
dc.contributor.authorGlass, E.en
dc.date.issued2012en
dc.identifier.citationPLoS One, 2012; 7(3):e33526-1-e33526-10en
dc.identifier.issn1932-6203en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://hdl.handle.net/2440/96236-
dc.description.abstractInfectious disease is an important problem for animal breeders, farmers and governments worldwide. One approach to reducing disease is to breed for resistance. This linkage study used a Charolais-Holstein F2 cattle cross population (n = 501) which was genotyped for 165 microsatellite markers (covering all autosomes) to search for associations with phenotypes for Bovine Respiratory Syncytial Virus (BRSV) specific total-IgG, IgG1 and IgG2 concentrations at several time-points pre- and post-BRSV vaccination. Regions of the bovine genome which influenced the immune response induced by BRSV vaccination were identified, as well as regions associated with the clearance of maternally derived BRSV specific antibodies. Significant positive correlations were detected within traits across time, with negative correlations between the pre- and post-vaccination time points. The whole genome scan identified 27 Quantitative Trait Loci (QTL) on 13 autosomes. Many QTL were associated with the Thymus Helper 1 linked IgG2 response, especially at week 2 following vaccination. However the most significant QTL, which reached 5% genome-wide significance, was on BTA 17 for IgG1, also 2 weeks following vaccination. All animals had declining maternally derived BRSV specific antibodies prior to vaccination and the levels of BRSV specific antibody prior to vaccination were found to be under polygenic control with several QTL detected.Heifers from the same population (n = 195) were subsequently immunised with a 40-mer Foot-and-Mouth Disease Virus peptide (FMDV) in a previous publication. Several of these QTL associated with the FMDV traits had overlapping peak positions with QTL in the current study, including the QTL on BTA23 which included the bovine Major Histocompatibility Complex (BoLA), and QTL on BTA9 and BTA24, suggesting that the genes underlying these QTL may control responses to multiple antigens. These results lay the groundwork for future investigations to identify the genes underlying the variation in clearance of maternal antibody and response to vaccination.en
dc.description.statementofresponsibilityRichard J. Leach, Ronan G. O’Neill, Julie L. Fitzpatrick, John L. Williams, Elizabeth J. Glassen
dc.language.isoenen
dc.publisherPublic Library of Scienceen
dc.rights© 2012 Leach et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.subjectRespiratory Syncytial Virus, Bovineen
dc.titleQuantitative trait loci associated with the immune response to a bovine respiratory syncytial virus vaccineen
dc.typeJournal articleen
dc.identifier.rmid0030037596en
dc.identifier.doi10.1371/journal.pone.0033526en
dc.identifier.pubid217944-
pubs.library.collectionAnimal and Veterinary Sciences publicationsen
pubs.library.teamDS02en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidWilliams, J. [0000-0001-5188-7957]en
Appears in Collections:Animal and Veterinary Sciences publications

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