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Type: Journal article
Title: Regulation and roles of elongation factor 2 kinase
Author: Proud, C.
Citation: Biochemical Society Transactions, 2015; 43(3):328-332
Publisher: Portland Press
Issue Date: 2015
ISSN: 0300-5127
Statement of
Christopher G. Proud
Abstract: Eukaryotic elongation factor 2 kinase (eEF2K) belongs to the small family of atypical protein kinases termed α-kinases, and is the only calcium/calmodulin (Ca/CaM)-dependent member of that group. It phosphorylates and inactivates eEF2, to slow down the rate of elongation, the stage in mRNA translation that consumes almost all the energy and amino acids consumed by protein synthesis. In addition to activation by Ca/CaM, eEF2K is also regulated by an array of other regulatory inputs, which include inhibition by the nutrient- and growth-factor activated signalling pathways. Recent evidence shows that eEF2K plays an important role in learning and memory, processes that require the synthesis of new proteins and involve Ca-mediated signalling. eEF2K is activated under conditions of nutrient and energy depletion. In cancer cells, or certain tumours, eEF2K exerts cytoprotective effects, which probably reflect its ability to inhibit protein synthesis, and nutrient consumption, under starvation conditions. eEF2K is being evaluated as a potential therapeutic target in cancer.
Keywords: eEF2; mRNA translation; nutrient; protein synthesis; synaptic plasticity; tumour
Rights: © The Authors Journal compilation © 2015 Biochemical Society
RMID: 0030035722
DOI: 10.1042/BST20140323
Appears in Collections:Molecular and Biomedical Science publications

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