Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/96318
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Clinical utility of folate-containing oral contraceptives
Author: Lassi, Z.
Bhutta, Z.
Citation: International Journal of Women's Health, 2012; 4(1):185-190
Publisher: Dove Medical Press
Issue Date: 2012
ISSN: 1179-1411
1179-1411
Statement of
Responsibility: 
Zohra S Lassi, Zulfiqar A Bhutta
Abstract: Folate is a generic term for a water-soluble B-complex vitamin which plays an important role in protein synthesis and metabolism and other processes related to cell multiplication and tissue growth. Pregnant and lactating women are at increased risk of folic acid deficiency because generally their dietary folate is insufficient to meet their physiological requirements and the metabolic demands of the growing fetus. The evidence pertaining to the reduction of the risk of neural tube defects (NTDs) due to folate is so compelling that supplementation with 400 μg of folic acid to all women trying to conceive until 12 weeks of pregnancy has been recommended by every relevant authority. A recent Cochrane review has also found protective effects of folate supplementation in occurrence and reoccurrence of NTDs. Despite food fortification and targeted public health campaigns promoting folic acid supplementation, 4,300,000 new cases occur each year worldwide resulting in an estimated 41,000 deaths and 2.3 million disability-adjusted life years (DALYS). This article will review the burden and risk factors of NTDS, and the role of folate in preventing NTDs. It will also describe different modes of supplementing folate and the newer evidence of the effectiveness of adding folate in oral contraceptives for raising serum and red blood cell folate levels.
Keywords: contraceptives; folate; folate-containing oral contraceptives; oral contraceptives
Rights: © 2012 Lassi and Bhutta, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
RMID: 0030038060
DOI: 10.2147/IJWH.S18611
Appears in Collections:Paediatrics publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.