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dc.contributor.authorBowen, J.-
dc.contributor.authorNoakes, M.-
dc.contributor.authorClifton, P.-
dc.identifier.citationThe Journal of Nutrition, 2004; 134(3):568-573-
dc.description.abstractWeight loss induces bone resorption and this can be attenuated by calcium supplementation. Protein-rich diets were recently associated with favorable effects on bone density, although this remains controversial. We hypothesized that a diet high in calcium and protein would minimize bone resorption during weight loss compared with a lower calcium, protein-rich diet. The effects of dietary calcium in high protein diets on calcium excretion and bone metabolism were examined in overweight adults (n = 50, BMI 33.4 +/- 2.1 kg/m(2)) during 12 wk of energy restriction followed by 4 wk of energy balance. Subjects were randomly assigned to isoenergetic diets (5.5 MJ/d, 34% energy from protein, 41% carbohydrate, 24% fat) high in either dairy protein (DP, 2400 mg Ca/d) or mixed protein sources (MP, 500 mg Ca/d). During energy restriction, weight loss was 10% (-9.7 +/- 3.8 kg, P < 0.01), and 24-h urinary calcium excretion decreased independently of diet (-1.09 +/- 0.23 mmol/d, P < 0.01). By wk 16, the MP diet group had a 40% greater increase in deoxypyridinoline (bone resorption marker) than the DP diet group (P = 0.008). Osteocalcin (bone formation marker) increased from wk 0 to 16 in only the MP diet group [+2.16 +/- 0.63 micro g/L (+0.63 +/- 0.11nmol/L), P = 0.001]. In conclusion, weight loss was associated with increased bone resorption, yet the DP diet had a modest advantage over the MP diet by minimizing overall turnover. Combined with reduced urinary calcium excretion, this suggests that a high-protein, calcium-replete diet may protect against bone loss during weight reduction.-
dc.description.statementofresponsibilityJane Bowen, Manny Noakes and Peter M. Clifton-
dc.publisherAmer Inst Nutrition-
dc.rights© 2004 The American Society for Nutritional Sciences-
dc.subjectBone turnover-
dc.subjectweight loss-
dc.titleA high dairy protein, high-calcium diet minimizes bone turnover in overweight adults during weight loss-
dc.typeJournal article-
dc.identifier.orcidClifton, P. [0000-0002-6411-626X]-
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