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Type: Journal article
Title: Effect of cisapride on gastric emptying in premature infants with feed intolerance
Author: Barnett, C.
Omari, T.
Davidson, G.
Goodchild, L.
Lontis, R.
Dent, J.
Haslam, R.
Citation: Journal of Paediatrics and Child Health, 2001; 37(6):559-563
Publisher: Blackwell Science Asia
Issue Date: 2001
ISSN: 1034-4810
Abstract: <h4>Objective</h4>To assess the effect of cisapride on gastric emptying and gastro-oesophageal reflux (GOR) symptoms in preterm infants with feed intolerance.<h4>Methods</h4>Sixteen preterm infants (gestational age 24-35 weeks) with feed intolerance were enrolled in the study. Infants were randomized to receive 7 days of cisapride 0.2 mg/kg four times a day, immediately followed by 7 days of placebo or vice versa. Gastric emptying was measured using the [13C]-octanoic acid breath test prior to study entry and repeated on day 5, 6 or 7 after randomization and 5, 6 or 7 days after crossover. The symptoms of GOR were monitored during the study period using a standardized reflux chart. Weight was recorded daily.<h4>Results</h4>There was no change in gastric emptying in infants prescribed cisapride (gastric half-emptying time (t1/2) 31.9 +/- 4.7 vs 34.2 +/- 3.9 min for placebo vs cisapride, respectively; P = 0.65). Infants on cisapride had slower growth and there was no change in reflux symptoms.<h4>Conclusions</h4>The use of cisapride in preterm infants with feed intolerance cannot be recommended.
Keywords: Humans; Infant, Premature, Diseases; Cisapride; Gastrointestinal Agents; Breath Tests; Treatment Outcome; Enteral Nutrition; Drug Administration Schedule; Probability; Follow-Up Studies; Cross-Over Studies; Feeding and Eating Disorders of Childhood; Gastric Emptying; Dose-Response Relationship, Drug; Reference Values; Infant, Newborn; Female; Male
RMID: 0020011697
DOI: 10.1046/j.1440-1754.2001.00705.x
Appears in Collections:Medicine publications

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