Please use this identifier to cite or link to this item:
Scopus Web of Science® Altmetric
Type: Journal article
Title: Bone density and bone-related biochemical variables in normal men: a longitudinal study
Author: Scopacasa, F.
Wishart, J.
Need, A.
Horowitz, M.
Morris, H.
Nordin, B.
Citation: Journal of Gerontology Series A: Biological Sciences and Medical Sciences, 2002; 57A(6):M385-M391
Publisher: Gerontological Society of America
Issue Date: 2002
ISSN: 1079-5006
Statement of
F. Scopacasa, J.M. Wishart, A.G. Need, M. Horowitz, H.A. Morris and B.E.C. Nordin
Abstract: Background. The objective of this study was to determine the pattern of forearm bone loss and its relationship to markers of bone turnover and sex steroids in normal men. This was a longitudinal study over a median interval of 41 months. The study was conducted in Adelaide, Australia. Study participants were 123 healthy male subjects, between the ages of 20 and 83 years. Methods. Fat-corrected forearm bone mineral content (fcBMC), markers of bone formation (alkaline phosphatase, osteocalcin, procollagen type 1 C-terminal extension peptide) and bone resorption (collagen type I cross-linked telopeptide, hydroxyproline/creatinine, pyridinoline/creatinine, and deoxypyridinoline/creatinine), calculated serum bioavailable testosterone, and serum estradiol were measured. Results. The mean time-weighted rate of change in forearm fcBMC was −0.33% ± 0.72 (SD) per year. Bone loss commenced after 30 years of age and increased with age (p < .001), particularly after age 70 years. There was no relationship between the rate of change in fcBMC and either markers of bone turnover or serum sex steroids. Conclusions. In normal men, bone loss increases with age; there does not appear to be any relationship between this loss and either markers of bone turnover or levels of free androgen or estrogen.
Keywords: Humans
Bone Resorption
Risk Assessment
Cohort Studies
Longitudinal Studies
Bone Development
Bone Density
Reference Values
Middle Aged
Rights: © 2002 by The Gerontological Society of America
DOI: 10.1093/gerona/57.6.M385
Published version:
Appears in Collections:Aurora harvest
Medicine publications

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.