Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/9662
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Type: Journal article
Title: Bone density and bone-related biochemical variables in normal men: a longitudinal study
Author: Scopacasa, F.
Wishart, J.
Need, A.
Horowitz, M.
Morris, H.
Nordin, B.
Citation: Journals of Gerontology Series A-Biological Sciences and Medical Sciences, 2002; 57A(6):M385-M391
Publisher: Gerontological Society of America
Issue Date: 2002
ISSN: 1079-5006
1758-535X
Statement of
Responsibility: 
F. Scopacasa, J.M. Wishart, A.G. Need, M. Horowitz, H.A. Morris and B.E.C. Nordin
Abstract: Background. The objective of this study was to determine the pattern of forearm bone loss and its relationship to markers of bone turnover and sex steroids in normal men. This was a longitudinal study over a median interval of 41 months. The study was conducted in Adelaide, Australia. Study participants were 123 healthy male subjects, between the ages of 20 and 83 years. Methods. Fat-corrected forearm bone mineral content (fcBMC), markers of bone formation (alkaline phosphatase, osteocalcin, procollagen type 1 C-terminal extension peptide) and bone resorption (collagen type I cross-linked telopeptide, hydroxyproline/creatinine, pyridinoline/creatinine, and deoxypyridinoline/creatinine), calculated serum bioavailable testosterone, and serum estradiol were measured. Results. The mean time-weighted rate of change in forearm fcBMC was −0.33% ± 0.72 (SD) per year. Bone loss commenced after 30 years of age and increased with age (p < .001), particularly after age 70 years. There was no relationship between the rate of change in fcBMC and either markers of bone turnover or serum sex steroids. Conclusions. In normal men, bone loss increases with age; there does not appear to be any relationship between this loss and either markers of bone turnover or levels of free androgen or estrogen.
Keywords: Humans; Osteoporosis; Bone Resorption; Testosterone; Estradiol; Densitometry; Incidence; Probability; Risk Assessment; Cohort Studies; Longitudinal Studies; Aging; Bone Development; Climacteric; Bone Density; Reference Values; Aged; Middle Aged; Male
Rights: © 2002 by The Gerontological Society of America
RMID: 0020020138
DOI: 10.1093/gerona/57.6.M385
Published version: http://biomed.gerontologyjournals.org/cgi/content/abstract/57/6/M385
Appears in Collections:Medicine publications

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