Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/96644
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Type: Journal article
Title: Cerebellar output in zebrafish: an analysis of spatial patterns and topography in eurydendroid cell projections
Author: Heap, L.
Goh, C.
Kassahn, K.
Scott, E.
Citation: Frontiers in Neural Circuits, 2013; 7:53-1-53-14
Publisher: Frontiers
Issue Date: 2013
ISSN: 1662-5110
1662-5110
Statement of
Responsibility: 
Lucy A. Heap, Chi Ching Goh, Karin S. Kassahn, and Ethan K. Scott
Abstract: The cerebellum is a brain region responsible for motor coordination and for refining motor programs. While a great deal is known about the structure and connectivity of the mammalian cerebellum, fundamental questions regarding its function in behavior remain unanswered. Recently, the zebrafish has emerged as a useful model organism for cerebellar studies, owing in part to the similarity in cerebellar circuits between zebrafish and mammals. While the cell types composing their cerebellar cortical circuits are generally conserved with mammals, zebrafish lack deep cerebellar nuclei, and instead a majority of cerebellar output comes from a single type of neuron: the eurydendroid cell. To describe spatial patterns of cerebellar output in zebrafish, we have used genetic techniques to label and trace eurydendroid cells individually and en masse. We have found that cerebellar output targets the thalamus and optic tectum, and have confirmed the presence of pre-synaptic terminals from eurydendroid cells in these structures using a synaptically targeted GFP. By observing individual eurydendroid cells, we have shown that different medial-lateral regions of the cerebellum have eurydendroid cells projecting to different targets. Finally, we found topographic organization in the connectivity between the cerebellum and the optic tectum, where more medial eurydendroid cells project to the rostral tectum while lateral cells project to the caudal tectum. These findings indicate that there is spatial logic underpinning cerebellar output in zebrafish with likely implications for cerebellar function.
Keywords: zebrafish
cerebellum
eurydendroid
optic tectum
thalamus
topography
Gal4
Rights: © 2013 Heap, Goh, Kassahn and Scott. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
DOI: 10.3389/fncir.2013.00053
Grant ID: http://purl.org/au-research/grants/arc/FT110100887
http://purl.org/au-research/grants/arc/DP110103612
Appears in Collections:Aurora harvest 3
Molecular and Biomedical Science publications

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