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Type: Journal article
Title: Intracellular P-gp contributes to functional drug efflux and resistance in acute myeloid leukaemia
Author: Ferrao, P.
Sincock, Paul
Cole, Stephen R.
Ashman, Leonie Kay
Citation: Leukemia Research. 25:395-405
Issue Date: 2001
ISSN: 0145-2126
School/Discipline: School of Medicine
Organisation: Division of Haematology, Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science
Abstract: Drug compartmentalization as well as drug efflux can contribute to drug resistance. We demonstrate the presence of P-gp in intracellular vesicles in certain AML cell lines and show localization of DNR to a similar subcellular compartment(s) that can be altered in the presence of P-gp inhibitors. Analysis of leukaemic cell lines and 50 AML patient samples showed that the level of P-gp mRNA or total P-gp protein correlated better with drug efflux than surface P-gp protein, suggesting that intracellular P-gp may contribute to MDR in AML. Therefore, the level of total P-gp protein or mRNA may be a better indicator of MDR than surface P-gp protein. In addition, we provide evidence for a novel mechanism of drug sequestration in K562 myeloid leukaemic cells.
DOI: 10.1016/S0145-2126(00)00156-9
Appears in Collections:Medicine publications

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