Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/9690
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dc.contributor.authorYandell, R.en
dc.contributor.authorBaker, B.en
dc.contributor.authorWittert, G.en
dc.contributor.authorWishart, J.en
dc.contributor.authorMorris, H.en
dc.contributor.authorHorowitz, M.en
dc.contributor.authorChapman, I.en
dc.date.issued2002en
dc.identifier.citationMetabolism-clinical and Experimental, 2002; 51(8):949-957en
dc.identifier.issn0026-0495en
dc.identifier.issn1532-8600en
dc.identifier.urihttp://hdl.handle.net/2440/9690-
dc.description.abstractTo investigate the relative effects of fructose and glucose on blood glucose, plasma insulin and incretin (glucagon-like peptide-1 [GLP-1] and gastric inhibitory peptide [GIP]) concentrations, and acute food intake, 10 (6 men, 4 women) patients with diet-controlled type 2 diabetes (diabetic) (44 to 71 years) and 10 age and body mass index (BMI)-matched (6 men, 4 women) nondiabetic, control subjects with varying degrees of glucose tolerance (nondiabetic), were studied on 3 days. In random order, they drank equienergetic preloads of glucose (75 g) (GLUC), fructose (75 g) (FRUCT) or vehicle (300 mL water with noncaloric flavoring [VEH]) 3 hours before an ad libitum buffet lunch. Mean glucose concentrations were lower after FRUCT than GLUC in both type 2 diabetics (FRUCT v GLUC: 7.5 +/- 0.3 v 10.8 +/- 0.4 mmol/L, P <.001) and nondiabetics (FRUCT v GLUC: 5.9 +/- 0.2 v 7.2 +/- 0.3 mmol/L, P <.05). Mean insulin concentrations were approximately 50% higher after FRUCT in type 2 diabetics than in nondiabetics (diabetics v nondiabetics: 23.1 +/- 0.7 v 15.1 +/- 1.3 microU/mL; P <.0001). Plasma GLP-1 concentrations after fructose were not different between type 2 diabetics and nondiabetics (P >.05). Glucose, but not FRUC, increased GIP concentrations, which were not different between type 2 diabetics and nondiabetics (P >.05). Food intake was suppressed 14% by GLUC (P <.05 v CONT) and 14% by FRUC (P <.05 v CONT), with no difference between the amount of food consumed after GLUC and FRUC treatment in either type 2 diabetics or nondiabetics (P >.05). We have confirmed that oral fructose ingestion produces a lower postprandial blood glucose response than equienergetic glucose and demonstrated that (1) fructose produces greater increases in plasma insulin concentration in type 2 diabetics than nondiabetics, not apparently due to greater plasma incretin concentrations and (2) fructose and glucose have equivalent short-term satiating efficiency in both type 2 diabetics and nondiabetics. We conclude that on the basis of improved glycemic control, but not satiating efficiency, fructose may be useful as a replacement for glucose in the diet of obese patients with type 2 diabetes.en
dc.description.statementofresponsibilityRosalie Vozzo, Ben Baker, Gary A. Wittert, Judith M. Wishart, Howard Morris, Michael Horowitz, and Ian Chapmanen
dc.language.isoenen
dc.publisherW B Saunders Coen
dc.rights© 2002 Elsevier Science (USA). All rights reserved.en
dc.subjectHumans; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Glucagon; Insulin; Fructose; Glucose; Blood Glucose; Peptide Fragments; Appetite; Adult; Aged; Middle Aged; Female; Male; Glucagon-Like Peptide 1; Glucagon-Like Peptidesen
dc.titleGlycemic, hormone, and appetite responses to monosaccharide ingestion in patients with type 2 diabetesen
dc.typeJournal articleen
dc.identifier.rmid0020020446en
dc.identifier.doi10.1053/meta.2002.34012en
dc.identifier.pubid60392-
pubs.library.collectionMedicine publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidYandell, R. [0000-0003-3801-5593]en
dc.identifier.orcidWittert, G. [0000-0001-6818-6065]en
dc.identifier.orcidMorris, H. [0000-0002-2745-3750]en
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]en
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