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Type: Journal article
Title: Proteoglycans: potential agents in mammographic density and the associated breast cancer risk
Author: Shawky, M.
Ricciardelli, C.
Lord, M.
Whitelock, J.
Ferro, V.
Britt, K.
Thompson, E.
Citation: Journal of Mammary Gland Biology and Neoplasia, 2015; 20(3-4):121-131
Publisher: Springer
Issue Date: 2015
ISSN: 1083-3021
Statement of
Michael S. Shawky, Carmela Ricciardelli, Megan Lord, John Whitelock, Vito Ferro, Kara Britt, Erik W. Thompson
Abstract: Although increased mammographic density (MD) has been well established as a marker for increased breast cancer (BC) risk, its pathobiology is far from understood. Altered proteoglycan (PG) composition may underpin the physical properties of MD, and may contribute to the associated increase in BC risk. Numerous studies have investigated PGs, which are a major stromal matrix component, in relation to MD and BC and reported results that are sometimes discordant. Our review summarises these results and highlights discrepancies between PG associations with BC and MD, thus serving as a guide for identifying PGs that warrant further research towards developing chemo-preventive or therapeutic agents targeting pre-invasive or invasive breast lesions, respectively.
Keywords: Breast cancer; Extracellular matrix; Glypican; Heparanase; Mammographic density; Perlecan; Proteoglycans; Syndecan; Versican
Rights: © Springer Science+Business Media New York 2015
RMID: 0030037954
DOI: 10.1007/s10911-015-9346-z
Appears in Collections:Medicine publications

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