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Type: Journal article
Title: Inflammation, plaque progression and vulnerability: evidence from intravascular ultrasound imaging
Author: Kataoka, Y.
Puri, R.
Nicholls, S.
Citation: Cardiovascular Diagnosis and Therapy, 2015; 5(4):280-289
Publisher: Cardiovascular Diagnosis and Therapy
Issue Date: 2015
ISSN: 2223-3652
Statement of
Yu Kataoka, Rishi Puri, Stephen J. Nicholls
Abstract: Increasing evidence points to a critical role of inflammation in the development and propagation of atherosclerotic cardiovascular disease. Pathological studies in human and animal models have elucidated specific inflammatory mediators contributing to the progression and rupture of atherosclerotic plaque in the artery wall. These observations not only outline the importance of inflammation in atheroma progression but also the potential of anti-inflammatory therapeutic approaches to prevent and stabilize atherosclerotic disease. Intravascular ultrasonography enables direct atheroma visualization in vivo. Additionally, refinements in ultrasound technology permitting radiofrequency backscatter analysis enhance plaque characterization associated with disease instability. These imaging modalities will continue to provide opportunities for evaluating novel inflammatory mechanisms and anti-inflammatory therapies.
Keywords: Intravascular ultrasound (IVUS); atherosclerosis; imaging; inflammation; plaque progression; plaque vulnerability
Rights: © Cardiovascular Diagnosis and Therapy. All rights reserved.
RMID: 0030037980
DOI: 10.3978/j.issn.2223-3652.2015.05.06
Appears in Collections:Medicine publications

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