Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/96960
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dc.contributor.authorGutiérrez-Gil, B.en
dc.contributor.authorWiener, P.en
dc.contributor.authorWilliams, J.en
dc.contributor.authorHaley, C.en
dc.date.issued2012en
dc.identifier.citationAnimal Genetics, 2012; 43(6):654-661en
dc.identifier.issn0268-9146en
dc.identifier.issn1365-2052en
dc.identifier.urihttp://hdl.handle.net/2440/96960-
dc.description.abstractA previous analysis of an F(2) /Backcross Charolais × Holstein cross population identified the presence of a highly significant QTL on chromosome 6 (BTA6) affecting the proportion of bone in the carcass. Two closely linked QTL affected birth weight (BW) and body length at birth (BBL). In this report, the marker density around the QTL on BTA6 was increased, adding four additional microsatellite markers across the chromosome and 46 SNPs within the target QTL confidence interval. Of the SNPs, 26 were in positional candidate genes and the remaining 20 provided an even distribution of markers in the target QTL region. As a bone-related trait, the sum of the bone weight for all the left fore- and hindquarter joints of the carcass was analysed. We also studied the BW and BBL. Analyses of the data substantially reduced the QTL confidence interval. No strong evidence was found that the QTL for the three traits studied are different, and we conclude that the results are consistent with a single pleiotropic QTL influencing the three traits, with the largest effects on the proportion of bone in the carcass. The analyses also suggest that none of the SNPs tested is the sole causative variant of the QTL effects. Specifically, the SNP in the NCAPG gene previously reported as a causal mutation for foetal growth and carcass traits in other cattle populations was excluded as the causal mutation for the QTL reported here. Polymorphisms located in other previously identified candidate genes including SPP1, ABCG2, IBSP, MEPE and PPARGC1A were also excluded. The results suggest that SNP51_BTA-119876 is the polymorphism in strongest linkage disequilibrium with the causal mutation(s). Further research is required to identify the causal variant(s) associated with this bone-related QTL.en
dc.description.statementofresponsibilityB. Gutiérrez-Gil, P. Wiener, J. L. Williams, and C. S. Haleyen
dc.language.isoenen
dc.publisherWileyen
dc.rights© 2012 The Authorsen
dc.subjectbone carcass weight; candidate gene; fine mapping; quantitative trait locusen
dc.titleInvestigation of the genetic architecture of a bone carcass weight QTL on BTA6en
dc.typeJournal articleen
dc.identifier.rmid0030037592en
dc.identifier.doi10.1111/j.1365-2052.2012.02322.xen
dc.identifier.pubid217940-
pubs.library.collectionAnimal and Veterinary Sciences publicationsen
pubs.library.teamDS02en
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidWilliams, J. [0000-0001-5188-7957]en
Appears in Collections:Animal and Veterinary Sciences publications

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