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https://hdl.handle.net/2440/9698
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DC Field | Value | Language |
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dc.contributor.author | Guthridge, M. | - |
dc.contributor.author | Stomski, F. | - |
dc.contributor.author | Barry, E. | - |
dc.contributor.author | Winnall, W. | - |
dc.contributor.author | Woodcock, J. | - |
dc.contributor.author | Mc Clure, B. | - |
dc.contributor.author | Dottore, M. | - |
dc.contributor.author | Berndt, M. | - |
dc.contributor.author | Lopez, A. | - |
dc.date.issued | 2000 | - |
dc.identifier.citation | Molecular Cell, 2000; 6(1):99-108 | - |
dc.identifier.issn | 1097-2765 | - |
dc.identifier.issn | 1097-4164 | - |
dc.identifier.uri | http://hdl.handle.net/2440/9698 | - |
dc.description.abstract | In the hemopoietic compartment, IL-3, GM-CSF, and IL-5 receptors are major transducers of survival signals; however, the receptor-proximal events that determine this vital function have not been defined. We have found that IL-3 stimulation induces phosphorylation of Ser-585 of beta(c). This promotes the association of phospho-Ser-585 of beta(c) with 14-3-3 and the p85 subunit of PI 3-K. Mutation of Ser-585 specifically impairs the PI 3-K signaling pathway and reduces cell survival in response to IL-3. These results define a distinct IL-3 receptor-mediated survival pathway regulated by site-specific receptor serine phosphorylation and 14-3-3 binding and suggest that this novel mode of signaling may be utilized by disparate transmembrane receptors that have as a common theme the transduction of survival signals. | - |
dc.language.iso | en | - |
dc.publisher | Cell Press | - |
dc.source.uri | http://dx.doi.org/10.1016/s1097-2765(05)00002-x | - |
dc.subject | Cell Line | - |
dc.subject | Hematopoietic System | - |
dc.subject | Animals | - |
dc.subject | Mice | - |
dc.subject | Tyrosine 3-Monooxygenase | - |
dc.subject | Cyclic AMP-Dependent Protein Kinases | - |
dc.subject | Serine | - |
dc.subject | 14-3-3 Proteins | - |
dc.subject | Proteins | - |
dc.subject | Interleukin-3 | - |
dc.subject | Receptors, Interleukin-3 | - |
dc.subject | Mutagenesis, Site-Directed | - |
dc.subject | Signal Transduction | - |
dc.subject | Cell Division | - |
dc.subject | Cell Survival | - |
dc.subject | Binding Sites | - |
dc.subject | Amino Acid Sequence | - |
dc.subject | Phosphorylation | - |
dc.subject | Phosphatidylinositol 3-Kinases | - |
dc.title | Site-specific serine phosphorylation of the IL-3 receptor is required for hemopoietic cell survival | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/S1097-2765(05)00002-X | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Lopez, A. [0000-0001-7430-0135] | - |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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