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dc.contributor.authorGuthridge, M.en
dc.contributor.authorStomski, F.en
dc.contributor.authorBarry, E.en
dc.contributor.authorWinnall, W.en
dc.contributor.authorWoodcock, J.en
dc.contributor.authorMc Clure, B.en
dc.contributor.authorDottore, M.en
dc.contributor.authorBerndt, M.en
dc.contributor.authorLopez, A.en
dc.identifier.citationMolecular Cell, 2000; 6(1):99-108en
dc.description.abstractIn the hemopoietic compartment, IL-3, GM-CSF, and IL-5 receptors are major transducers of survival signals; however, the receptor-proximal events that determine this vital function have not been defined. We have found that IL-3 stimulation induces phosphorylation of Ser-585 of beta(c). This promotes the association of phospho-Ser-585 of beta(c) with 14-3-3 and the p85 subunit of PI 3-K. Mutation of Ser-585 specifically impairs the PI 3-K signaling pathway and reduces cell survival in response to IL-3. These results define a distinct IL-3 receptor-mediated survival pathway regulated by site-specific receptor serine phosphorylation and 14-3-3 binding and suggest that this novel mode of signaling may be utilized by disparate transmembrane receptors that have as a common theme the transduction of survival signals.en
dc.publisherCell Pressen
dc.subjectCell Line; Hematopoietic System; Animals; Mice; Tyrosine 3-Monooxygenase; Cyclic AMP-Dependent Protein Kinases; Serine; 14-3-3 Proteins; Proteins; Interleukin-3; Receptors, Interleukin-3; Mutagenesis, Site-Directed; Signal Transduction; Cell Division; Cell Survival; Binding Sites; Amino Acid Sequence; Phosphorylation; Phosphatidylinositol 3-Kinasesen
dc.titleSite-specific serine phosphorylation of the IL-3 receptor is required for hemopoietic cell survivalen
dc.typeJournal articleen
pubs.library.collectionMedicine publicationsen
dc.identifier.orcidLopez, A. [0000-0001-7430-0135]en
Appears in Collections:Medicine publications

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