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|dc.identifier.citation||Journal of Fish Diseases, 2015; 38(6):561-565||-|
|dc.description||Article first published online: 13 AUG 2014||-|
|dc.description.abstract||Amyloid associated with pancreatic adenocarcinoma was discovered in two captive adult tricolour sharkminnows Balantiocheilus melanopterus Bleeker found dead in a freshwater display. Enlarged abdomens expanded by bloody ascitic fluid and grossly visible masses of abnormal tissue were present surrounding sections of the stomach and intestine. Histologically, the masses were composed of areas of well-organized exocrine pancreatic acini interspersed with cords of poorly differentiated, spindle-shaped cells that compressed and effaced normal parenchyma. These cells possessed small numbers of cytoplasmic zymogen granules; the exocrine nature of these cells was confirmed using transmission electron microscopy (TEM). Fibrovascular connective tissue of the hepatopancreas and mesenteries was expanded by lightly eosinophilic, hyaline, homogeneous acellular material. Similar material greatly expanded the tunica media of large blood vessels in the hepatopancreas. After staining with Congo red or thioflavin T, this material exhibited red-green dichroism under polarized light or bright green fluorescence under ultraviolet light (255 nm), respectively. The non-branching fibrils, of indeterminate length, had an approximate diameter of 10-20 nm using TEM. Although exocrine pancreatic neoplasia is relatively common in fish, the presence of amyloid is not. To our current knowledge, the latter has not yet been described in association with a neoplastic lesion in fish.||-|
|dc.description.statementofresponsibility||S Russell, L Tubbs, D J McLelland, V LePage, K M Young, P Huber and J S Lumsden||-|
|dc.rights||© 2014 John Wiley & Sons Ltd||-|
|dc.subject||amyloid; tricolour sharkminnow; neoplasia||-|
|dc.title||Amyloid associated with neoplasia in two captive tricolour sharkminnows Balantiocheilus melanopterus Bleeker||-|
|Appears in Collections:||Animal and Veterinary Sciences publications|
Aurora harvest 7
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