Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/97088
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Y-Chromosome and mtDNA genetics reveal significant contrasts in affinities of modern Middle Eastern populations with European and African populations
Author: Badro, D.
Douaihy, B.
Haber, M.
Youhanna, S.
Salloum, A.
Ghassibe-Sabbagh, M.
Johnsrud, B.
Khazen, G.
Matisoo-Smith, E.
Soria-Hernanz, D.
Wells, R.
Tyler-Smith, C.
Platt, D.
Zalloua, P.
Citation: PLoS One, 2013; 8(1):e54616-1-e54616-11
Publisher: Public Library of Science
Issue Date: 2013
ISSN: 1932-6203
1932-6203
Statement of
Responsibility: 
Danielle A. Badro, Bouchra Douaihy, ., Marc Haber, ., Sonia C. Youhanna, Ange, lique Salloum, Michella Ghassibe-Sabbagh, Brian Johnsrud, Georges Khazen, Elizabeth Matisoo-Smith, David F. Soria-Hernanz, R. Spencer Wells, Chris Tyler-Smith, Daniel E. Platt, Pierre A. Zalloua, The Genographic Consortium
Abstract: The Middle East was a funnel of human expansion out of Africa, a staging area for the Neolithic Agricultural Revolution, and the home to some of the earliest world empires. Post LGM expansions into the region and subsequent population movements created a striking genetic mosaic with distinct sex-based genetic differentiation. While prior studies have examined the mtDNA and Y-chromosome contrast in focal populations in the Middle East, none have undertaken a broad-spectrum survey including North and sub-Saharan Africa, Europe, and Middle Eastern populations. In this study 5,174 mtDNA and 4,658 Y-chromosome samples were investigated using PCA, MDS, mean-linkage clustering, AMOVA, and Fisher exact tests of F(ST)'s, R(ST)'s, and haplogroup frequencies. Geographic differentiation in affinities of Middle Eastern populations with Africa and Europe showed distinct contrasts between mtDNA and Y-chromosome data. Specifically, Lebanon's mtDNA shows a very strong association to Europe, while Yemen shows very strong affinity with Egypt and North and East Africa. Previous Y-chromosome results showed a Levantine coastal-inland contrast marked by J1 and J2, and a very strong North African component was evident throughout the Middle East. Neither of these patterns were observed in the mtDNA. While J2 has penetrated into Europe, the pattern of Y-chromosome diversity in Lebanon does not show the widespread affinities with Europe indicated by the mtDNA data. Lastly, while each population shows evidence of connections with expansions that now define the Middle East, Africa, and Europe, many of the populations in the Middle East show distinctive mtDNA and Y-haplogroup characteristics that indicate long standing settlement with relatively little impact from and movement into other populations.
Keywords: Genographic Consortium; Chromosomes, Human, Y; Humans; DNA, Mitochondrial; Cluster Analysis; Genetics, Population; Phylogeny; Gene Frequency; Haplotypes; Polymorphism, Single Nucleotide; Continental Population Groups; Africa; Middle East; Europe; Phylogeography
Rights: © 2013 Badro et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
RMID: 0030024811
DOI: 10.1371/journal.pone.0054616
Appears in Collections:Genetics publications

Files in This Item:
File Description SizeFormat 
hdl_97088.pdfPublished version711.71 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.