Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/97159
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Type: Journal article
Title: Selection signatures in worldwide sheep populations
Author: Fariello, M.
Servin, B.
Tosser-Klopp, G.
Rupp, R.
Moreno, C.
Cristobal, M.
Boitard, S.
Arranz, J.
Banos, G.
Barendse, W.
El Beltagy, A.
Benenwitz, J.
Bishop, S.
Bunger, L.
Calvo, J.
Carta, A.
Cemal, I.
Ciani, E.
Cockett, N.
Coltman, D.
et al.
Citation: PLoS One, 2014; 9(8):e103813-1-e103813
Publisher: Public Library of Science
Issue Date: 2014
ISSN: 1932-6203
1932-6203
Statement of
Responsibility: 
Maria-Ines Fariello, Bertrand Servin, Gwenola Tosser-Klopp, Rachel Rupp, Carole Moreno, International Sheep Genomics Consortium, Magali San Cristobal, Simon Boitard
Abstract: The diversity of populations in domestic species offers great opportunities to study genome response to selection. The recently published Sheep HapMap dataset is a great example of characterization of the world wide genetic diversity in sheep. In this study, we re-analyzed the Sheep HapMap dataset to identify selection signatures in worldwide sheep populations. Compared to previous analyses, we made use of statistical methods that (i) take account of the hierarchical structure of sheep populations, (ii) make use of linkage disequilibrium information and (iii) focus specifically on either recent or older selection signatures. We show that this allows pinpointing several new selection signatures in the sheep genome and distinguishing those related to modern breeding objectives and to earlier post-domestication constraints. The newly identified regions, together with the ones previously identified, reveal the extensive genome response to selection on morphology, color and adaptation to new environments.
Rights: © 2014 Fariello et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
RMID: 0030035290
DOI: 10.1371/journal.pone.0103813
Appears in Collections:Animal and Veterinary Sciences publications

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