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dc.contributor.authorBakker, M.en
dc.contributor.authorHofmann, J.en
dc.contributor.authorChurches, O.en
dc.contributor.authorBadcock, N.en
dc.contributor.authorKohler, M.en
dc.contributor.authorKeage, H.en
dc.identifier.citationBMC Neurology, 2014; 14(1):43-1-43-12en
dc.description.abstractBACKGROUND: The contribution of cerebrovascular function to cognitive performance is gaining increased attention. Transcranial doppler (TCD) is portable, reliable, inexpensive and extremely well tolerated by young and clinical samples. It enables measurement of blood flow velocity in major cerebral arteries at rest and during cognitive tasks. METHODS: We systematically reviewed evidence for associations between cognitive performance and cerebrovascular function in children (0-18 years), as measured using TCD. A total of 2778 articles were retrieved from PsychInfo, Pubmed, and EMBASE searches and 25 relevant articles were identified. RESULTS: Most studies investigated clinical groups, where decreased blood flow velocities in infants were associated with poor neurological functioning, and increased blood flow velocities in children with Sickle cell disease were typically associated with cognitive impairment and lower intelligence. Studies were also identified assessing autistic behaviour, mental retardation and sleep disordered breathing. In healthy children, the majority of studies reported cognitive processing produced lateralised changes in blood flow velocities however these physiological responses did not appear to correlate with behavioural cognitive performance. CONCLUSION: Poor cognitive performance appears to be associated with decreased blood flow velocities in premature infants, and increased velocities in Sickle cell disease children using TCD methods. However knowledge in healthy samples is relatively limited. The technique is well tolerated by children, is portable and inexpensive. It therefore stands to make a valuable contribution to knowledge regarding the underlying functional biology of cognitive performance in childhood.en
dc.description.statementofresponsibilityMireille J Bakker, Jessica Hofmann, Owen F Churches, Nicholas A Badcock, Mark Kohler and Hannah AD Keageen
dc.publisherBioMed Centralen
dc.rights© 2014 Bakker et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.en
dc.subjectHumans; Anemia, Sickle Cell; Ultrasonography, Doppler, Transcranial; Blood Flow Velocity; Cognition; Cognition Disorders; Cerebrovascular Circulation; Adolescent; Child; Child, Preschool; Infant; Infant, Newborn; Female; Maleen
dc.titleCerebrovascular function and cognition in childhood: a systematic review of transcranial doppler studiesen
dc.typeJournal articleen
pubs.library.collectionPsychology publicationsen
dc.identifier.orcidKohler, M. [0000-0001-7265-6242]en
dc.identifier.orcidKeage, H. [0000-0002-6814-4997]en
Appears in Collections:Psychology publications

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