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Type: Journal article
Title: Plasma glucagon-like peptide-1 (GLP-1) responses to duodenal fat and glucose infusions in lean and obese men
Author: Feinle-Bisset, C.
Chapman, I.
Wishart, J.
Horowitz, M.
Citation: Peptides, 2002; 23(8):1491-1495
Publisher: Elsevier Science Inc
Issue Date: 2002
ISSN: 0196-9781
Statement of
Christine Feinle, Ian M. Chapman, Judith Wishart, Michael Horowitz
Abstract: It has been suggested that obesity is associated with a reduced glucagon-like peptide-1 (GLP-1) response to oral carbohydrate, but not fat. The latter may, however, be attributable to changes in gastric emptying. We have assessed plasma GLP-1 levels in response to these infusions in lean and obese subjects. Seven healthy lean (body mass index (BMI), 19.1-24.6 kg/m(2)) and seven obese (BMI, 31.3-40.8 kg/m(2)) young men received an intraduodenal infusion of glucose and fat for 120 min (2.86 kcal/min) on two separate days. Blood samples for plasma GLP-1 were obtained at baseline and every 20 min during the infusion. Plasma GLP-1 increased during infusion of glucose and fat (P = 0.001), but there were no differences between lean and obese subjects, nor the two nutrients. We conclude that GLP-1 secretion in response to duodenal infusion of glucose and fat is not altered in obese subjects.
Keywords: Glucagon-like peptide-1
Duodenal infusion
Description: Copyright © 2002 Elsevier Science Inc. All rights reserved.
DOI: 10.1016/S0196-9781(02)00087-6
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