Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Monitoring the intragastric distribution of a colloidal drug carrier model by magnetic resonance imaging|
de Smidt, C.
|Citation:||Pharmaceutical Research, 2001; 18(4):460-466|
|Publisher:||Kluwer Academic/Plenum Publ|
|Henryk Faas, Werner Schwizer, Christine Feinle, Hans Lengsfeld, Chris de Smidt, Peter Boesiger, Michael Fried, and Thomas Rades|
|Abstract:||Purpose: Monitoring the distribution of drugs or drug delivery systems in the human gastrointestinal tract is an important prerequisite for the design of orally administered drugs. We investigated the intragastric distribution of a colloidal drug delivery system (liposomes containing the contrast agent Gd-DOTA) by magnetic resonance imaging. Methods: Following ingestion of a liquid or a solid meal, gastric distribution of liposomes released from a capsule and the fat component of the solid meal were tracked in 7 healthy subjects for 90 min. Liposomes were identified in gastric content by the increased signal intensity provided by the encapsulated Gd-DOTA. Results. With the liquid meal, liposomes initially formed a layer on the surface before distributing in 86 ± 2% of gastric content (maximum distribution volume) within 42 ± 6 min. With the solid meal, maximum distribution (7 ± 1%, reached within 24 ± 6 min) was confined to a small volume in the fundus without forming a layer, suggesting that distribution was related to the accessible liquid compartment. Fat distribution was inhomogeneous and concentrated in the fundus. Conclusions: Intragastric distribution of a colloidal drug carrier model, such as Gd-DOTA-filled liposomes, varies between meals of different composition. These differences can be monitored in three dimensions in humans by MRI.|
|Keywords:||intragastric drug distribution; colloidal system; liposomes; solid meal; liquid meal; magnetic resonance imaging|
|Appears in Collections:||Medicine publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.