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Type: Journal article
Title: The chemokine receptor CCR6 facilitates the onset of mammary neoplasia in the MMTV-PyMT mouse model via recruitment of tumor-promoting macrophages
Author: Boyle, S.
Faulkner, J.
McColl, S.
Kochetkova, M.
Citation: Molecular Cancer, 2015; 14(1):115-1-115-14
Publisher: BioMed Central
Issue Date: 2015
ISSN: 1476-4598
Statement of
Sarah T. Boyle, Jessica W. Faulkner, Shaun R. McColl, and Marina Kochetkova
Abstract: BACKGROUND: The expression of the chemokine receptor CCR6 has been previously correlated with higher grades and stages of breast cancer and decreased relapse-free survival. Also, its cognate chemokine ligand CCL20 has been reported to induce proliferation of cultured human breast epithelial cells. METHODS: To establish if CCR6 plays a functional role in mammary tumorigenesis, a bigenic MMTV-PyMT CCR6-null mouse was generated and mammary tumor development was assessed. Levels of tumor-infiltrating immune cells within tumor-bearing mammary glands from MMTV-PyMT Ccr6 (WT) and Ccr6 (-/-) mice were also analyzed. RESULTS: Deletion of CCR6 delayed tumor onset, significantly reduced the extent of initial hyperplastic outgrowth, and decreased tumor incidence in PyMT transgenic mice. CCR6 was then shown to promote the recruitment of pro-tumorigenic macrophages to the tumor site, facilitating the onset of neoplasia. CONCLUSIONS: This study delineated for the first time a role for CCR6 in the development of breast cancer, and demonstrated a critical function for this receptor in maintaining the pro-tumorigenic cancer microenvironment.
Keywords: Breast Cancer; Mammary Gland; Chemokine Receptor; CCR6; Transgenic Mouse Model; Immune System Macrophages
Rights: © Boyle et al. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://​creativecommons.​org/​licenses/​by/​4.​0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://​creativecommons.​org/​publicdomain/​zero/​1.​0/​) applies to the data made available in this article, unless otherwise stated.
RMID: 0030030486
DOI: 10.1186/s12943-015-0394-1
Appears in Collections:Molecular and Biomedical Science publications

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