Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/97501
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Type: Journal article
Title: Lessons from history of socioeconomic improvements: A new approach to treating multi-drug-resistant tuberculosis
Author: Holloway, K.
Staub, K.
Rühli, F.
Henneberg, M.
Citation: Journal of Biosocial Science, 2014; 46(5):600-620
Publisher: Cambridge University Press
Issue Date: 2014
ISSN: 0021-9320
1469-7599
Statement of
Responsibility: 
K. L. Holloway, K. Staub, F.Rühli, and M. Henneberg
Abstract: This study investigated the trends in tuberculosis mortality through time in Switzerland. Information on the decline in mortality before chemotherapies were introduced may be useful in developing countries where drug- resistant tuberculosis is now becoming a major problem. Swiss data were collected from historical records and comparative data were obtained from the literature for England and Wales, New York, Japan, Brazil and Sierra Leone. Logistic curves were fitted to examine the rate of decline before introduction of pharmacotherapies and these show that the decline would have continued without the introduction of chemical therapies, including antibiotics. In Switzerland, England and Wales and New York, the decline had occurred long before the introduction of specific anti-tuberculosis agents. In Brazil and Japan, chemical therapy was co-incident with the decline in tuberculosis mortality rates. Overall, it is suggested that the effective control of tuberculosis can be achieved through a combination of chemical interventions, conservative therapy (rest, good nutrition, ventilation, etc.) as well as public health interventions addressing hygiene, nutrition, reducing exposure to infections and educating the population about tuberculosis.
Keywords: Humans; Tuberculosis; Tuberculosis, Multidrug-Resistant; Medical Records; Public Health Practice; Developing Countries; Socioeconomic Factors; Sierra Leone; New York; Brazil; Japan; England; Wales; Switzerland
Rights: © Cambridge University Press, 2013
RMID: 0030011434
DOI: 10.1017/S0021932013000527
Appears in Collections:Medicine publications

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