Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/97511
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Type: Journal article
Title: Preterm labor: current pharmacotherapy options for tocolysis
Author: van Vliet, E.
Boormans, E.
de Lange, T.
Mol, B.
Oudijk, M.
Citation: Expert Opinion on Pharmacotherapy, 2014; 15(6):787-797
Publisher: Taylor & Francis
Issue Date: 2014
ISSN: 1465-6566
1744-7666
Statement of
Responsibility: 
Elvira OG van Vliet, Elisabeth M Boormans, Thomas S de Lange, Ben W Mol and Martijn A Oudijk
Abstract: INTRODUCTION: In the developed world, preterm birth is in quantity and in severity the most important issue in obstetric care. Adverse neonatal outcome is strongly related to gestational age at delivery. Since the pathophysiological mechanism of preterm birth is not yet completely unraveled, the development of successful preventive strategies is hampered. When preterm labor is actually threatening, current pharmacological therapies focus on inhibition of preterm contractions. This allows for transportation of the mother to a center with a neonatal intensive care unit and administration of corticosteroids to enhance fetal lung maturation. Globally, however, large practice variation exists. AREAS COVERED: The aim of this review is to provide an overview of current pharmacological therapies for preterm labor. EXPERT OPINION: For the initial tocolysis, the use of atosiban or nifedipine for 48 h is recommended based on the largest effectiveness and most favorable side effect profile. However, since data that convincingly indicate the beneficial effect of tocolytics on neonatal outcome are lacking, it might well be that tocolytics are ineffective. The role of progesterone in treatment of acute tocolysis is limited, but it might play a role in the prevention of preterm labor or as sensitizer for other tocolytic agents.
Keywords: pharmacotherapy; preterm birth; preterm labor; tocolytics
Description: Published online: 17 Feb 2014
Rights: © 2014 Informa UK, Ltd.
RMID: 0030017831
DOI: 10.1517/14656566.2014.889684
Appears in Collections:Obstetrics and Gynaecology publications

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