Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/97562
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Comparative effects of intraduodenal whey protein hydrolysate on antropyloroduodenal motility, gut hormones, glycemia, appetite, and energy intake in lean and obese men
Author: Hutchison, A.
Feinle-Bisset, C.
Fitzgerald, P.
Standfield, S.
Horowitz, M.
Clifton, P.
Luscombe-Marsh, N.
Citation: American Journal of Clinical Nutrition, 2015; 102(6):1323-1331
Publisher: American Society for Nutrition
Issue Date: 2015
ISSN: 0002-9165
1938-3207
Statement of
Responsibility: 
Amy T Hutchison, Christine Feinle-Bisset, Penelope CE Fitzgerald, Scott Standfield, Michael Horowitz, Peter M Clifton, and Natalie D Luscombe-Marsh
Abstract: In lean individuals, intraduodenal protein and lipid modulate gastrointestinal motor and hormone functions and reduce energy intake in a load-dependent manner; protein also stimulates insulin, with modest effects on reducing blood glucose. The effect of intraduodenal lipid on gastrointestinal motor and hormone responses is diminished in obesity; whether the effects of protein are also attenuated remains unclear.The objectives of this study were to characterize the load-dependent effects of intraduodenal whey protein hydrolysate on antropyloroduodenal pressures, gut hormones, glycemia, appetite, and energy intake in obese subjects and to compare the responses to the higher protein load with those in lean subjects.We measured antropyloroduodenal pressures, plasma cholecystokinin (CCK), glucagon-like peptide 1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), glucagon, insulin, blood glucose, appetite, and energy intake in 12 nondiabetic obese men on 3 separate occasions, in a double-blind, randomized order, during 60-min intraduodenal infusions of hydrolyzed whey protein at either 0 (saline control), 1.5, or 3 kcal/min. Twelve age-matched lean individuals received a 3-kcal/min infusion only. Immediately after the infusions, energy intake from a buffet lunch was quantified.In obese subjects, protein suppressed antral and duodenal pressures; stimulated plasma CCK, GLP-1, GIP, insulin, and glucagon (all r > 0.57, P < 0.01); and tended to reduce energy intake (r = -10.38, P = 0.057) in a dose-dependent manner. In response to the 3-kcal/min protein load, antropyloroduodenal pressures, CCK, GLP-1, and glucagon did not differ between lean and obese subjects. Insulin release was greater, and GIP release less, in obese than in lean subjects (both P < 0.05), whereas the reduction in glucose was comparable. Energy intake tended to be higher in obese subjects (P = 0.08).The gastrointestinal effects of hydrolyzed whey protein remain relatively intact in obesity; however, the observed changes in insulin and GIP suggest early disturbances in the insulin-incretin axis. This study was registered at www.anzctr.org.au as ACTRN 12612000203853.
Keywords: blood glucose; cholecystokinin; food intake; gastrointestinal motility; glucagon-like peptide 1; obesity
Rights: © 2015 American Society for Nutrition
RMID: 0030039051
DOI: 10.3945/ajcn.115.114538
Grant ID: http://purl.org/au-research/grants/nhmrc/627118
http://purl.org/au-research/grants/nhmrc/627002
Appears in Collections:Medicine publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.