Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/97649
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Origins and functional evolution of Y chromosomes across mammals
Author: Cortez, D.
Marin, R.
Toledo-Flores, D.
Froidevaux, L.
Liechti, A.
Waters, P.
Gruetzner, F.
Kaessmann, H.
Citation: Nature, 2014; 508(7497):488-493
Publisher: Nature Publishing Group
Issue Date: 2014
ISSN: 0028-0836
1476-4687
Statement of
Responsibility: 
Diego Cortez, Ray Marin, Deborah Toledo-Flores, Laure Froidevaux, Ange, lica Liechti, Paul D. Waters, Frank Grützner & Henrik Kaessmann
Abstract: Y chromosomes underlie sex determination in mammals, but their repeat-rich nature has hampered sequencing and associated evolutionary studies. Here we trace Y evolution across 15 representative mammals on the basis of high-throughput genome and transcriptome sequencing. We uncover three independent sex chromosome originations in mammals and birds (the outgroup). The original placental and marsupial (therian) Y, containing the sex-determining gene SRY, emerged in the therian ancestor approximately 180 million years ago, in parallel with the first of five monotreme Y chromosomes, carrying the probable sex-determining gene AMH. The avian W chromosome arose approximately 140 million years ago in the bird ancestor. The small Y/W gene repertoires, enriched in regulatory functions, were rapidly defined following stratification (recombination arrest) and erosion events and have remained considerably stable. Despite expression decreases in therians, Y/W genes show notable conservation of proto-sex chromosome expression patterns, although various Y genes evolved testis-specificities through differential regulatory decay. Thus, although some genes evolved novel functions through spatial/temporal expression shifts, most Y genes probably endured, at least initially, because of dosage constraints.
Keywords: Testis
Description: Published online 23 April 2014
Rights: ©2014 Macmillan Publishers Limited. All rights reserved
RMID: 0030016413
DOI: 10.1038/nature13151
Appears in Collections:Molecular and Biomedical Science publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.