Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/97750
Citations | ||
Scopus | Web of ScienceĀ® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chen, J. | - |
dc.contributor.author | Zhang, X.D. | - |
dc.contributor.author | Proud, C. | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Science Signaling, 2015; 8(392):pe1-1-pe1-3 | - |
dc.identifier.issn | 1945-0877 | - |
dc.identifier.issn | 1937-9145 | - |
dc.identifier.uri | http://hdl.handle.net/2440/97750 | - |
dc.description.abstract | Double knockout of PTEN and LKB1-genes encoding phosphatase and tensin homolog and liver kinase B1, respectively-leads to the spontaneous development of cancer in mice. PTEN converts phosphatidylinositol (3,4,5)-trisphosphate (PIP3) to phosphatidylinositol (4,5)-bisphosphate (PIP2), whereas LKB1 activates the 5' adenosine monophosphate-activated protein kinase (AMPK). The kinase AKT and the kinase complex mTORC1 may play key roles in carcinogenesis and are components of signaling pathways that also contain PTEN and LKB1. We propose that via activation of AKT and mTORC1, the double knockout of PTEN and LKB1 contributes to distinct cell-specific aspects of tumor development and progression. Whereas mTORC1 promotes cancer initiation and progression through cell growth, survival, and proliferation, independent induction of the immune inhibitory molecule PD-L1 by activated AKT enables the tumors to evade immunosurveillance. | - |
dc.description.statementofresponsibility | Jiezhong Chen, Xu Dong Zhang, Christopher Proud | - |
dc.language.iso | en | - |
dc.publisher | American Association for the Advancement of Science | - |
dc.rights | Copyright 2016 by the American Association for the Advancement of Science; all rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1126/scisignal.aac8321 | - |
dc.subject | Animals | - |
dc.subject | Mice, Knockout | - |
dc.subject | Mice | - |
dc.subject | Neoplasms | - |
dc.subject | Multiprotein Complexes | - |
dc.subject | Signal Transduction | - |
dc.subject | Cell Proliferation | - |
dc.subject | Cell Survival | - |
dc.subject | Tumor Escape | - |
dc.subject | Proto-Oncogene Proteins c-akt | - |
dc.subject | PTEN Phosphohydrolase | - |
dc.subject | AMP-Activated Protein Kinases | - |
dc.subject | TOR Serine-Threonine Kinases | - |
dc.subject | Mechanistic Target of Rapamycin Complex 1 | - |
dc.subject | Protein Serine-Threonine Kinases | - |
dc.title | Dissecting the signaling pathways that mediate cancer in PTEN and LKB1 double-knockout mice | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1126/scisignal.aac8321 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1002857 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Proud, C. [0000-0003-0704-6442] | - |
Appears in Collections: | Aurora harvest 3 Molecular and Biomedical Science publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.