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Type: Journal article
Title: Esterase D is essential for protection of neisseria gonorrhoeae against nitrosative stress and for bacterial growth during interaction with cervical epithelial cells
Author: Potter, A.J.
Kidd, S.P.
Edwards, J.L.
Falsetta, M.L.
Apicella, M.A.
Jennings, M.P.
McEwan, A.G.
Citation: Journal of Infectious Diseases, 2009; 200(2):273-278
Publisher: Oxford University Press
Issue Date: 2009
ISSN: 0022-1899
Statement of
Adam J. Potter, Stephen P. Kidd, Jennifer L. Edwards, Megan L. Falsetta, Michael A. Apicella, Michael P. Jennings, and Alastair G. McEwan
Abstract: estD encodes a carboxylic ester hydrolase and is part of the NmlR regulon in Neisseria gonorrhoeae. An estD mutant was found to be susceptible to nitrite and to S-nitrosoglutathione. This mutant was also unable to infect and survive within human cervical epithelial cells, and it showed reduced ability to form a biofilm on these cells. We conclude that esterase D is an integral part of the nitrosative stress defense system of N. gonorrhoeae and that it has potential importance in pathogenesis.
Keywords: Cervix Uteri
Epithelial Cells
Neisseria gonorrhoeae
Sodium Nitrite
Thiolester Hydrolases
Gene Expression Regulation, Bacterial
Gene Expression Regulation, Enzymologic
Rights: © 2009 by the Infectious Diseases Society of America
DOI: 10.1086/599987
Appears in Collections:Aurora harvest 7
Molecular and Biomedical Science publications

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