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|Title:||Esterase D is essential for protection of neisseria gonorrhoeae against nitrosative stress and for bacterial growth during interaction with cervical epithelial cells|
|Citation:||The Journal of Infectious Diseases, 2009; 200(2):273-278|
|Publisher:||Oxford University Press|
|Adam J. Potter, Stephen P. Kidd, Jennifer L. Edwards, Megan L. Falsetta, Michael A. Apicella, Michael P. Jennings, and Alastair G. McEwan|
|Abstract:||estD encodes a carboxylic ester hydrolase and is part of the NmlR regulon in Neisseria gonorrhoeae. An estD mutant was found to be susceptible to nitrite and to S-nitrosoglutathione. This mutant was also unable to infect and survive within human cervical epithelial cells, and it showed reduced ability to form a biofilm on these cells. We conclude that esterase D is an integral part of the nitrosative stress defense system of N. gonorrhoeae and that it has potential importance in pathogenesis.|
|Rights:||© 2009 by the Infectious Diseases Society of America|
|Appears in Collections:||Molecular and Biomedical Science publications|
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