Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/9783
Citations | ||
Scopus | Web of ScienceĀ® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Harcourt, J. | - |
dc.contributor.author | Brown, M. | - |
dc.contributor.author | Anderson, L. | - |
dc.contributor.author | Tripp, R. | - |
dc.date.issued | 2003 | - |
dc.identifier.citation | Vaccine, 2003; 21(21-22):2964-2979 | - |
dc.identifier.issn | 0264-410X | - |
dc.identifier.issn | 1873-2518 | - |
dc.identifier.uri | http://hdl.handle.net/2440/9783 | - |
dc.description.abstract | Respiratory syncytial virus (RSV) infection is the single most important cause of serious acute respiratory illness in children <1 year of age worldwide, and is associated with life-threatening pneumonia or bronchiolitis in the elderly. Current vaccine strategies include live, attenuated virus, subunit and DNA vaccines, however, none have been sufficiently safe, or shown to induce satisfactory long-term immunity, thus immune modulators are being considered to enhance the effectiveness of RSV vaccines. In this study, we examine CD40 ligand (CD40L) as an immune modulator to enhance the durability of DNA vaccines encoding RSV F and/or G glycoproteins in BALB/c mice. The addition of CD40L to DNA vaccines encoding the F glycoprotein enhanced virus clearance and some aspects of the immune response to RSV challenge, suggesting that CD40L may enhance the durability of RSV DNA vaccines. | - |
dc.description.uri | http://www.sciencedirect.com/science/journal/0264410X | - |
dc.language.iso | en | - |
dc.publisher | Elsevier Sci Ltd | - |
dc.source.uri | http://dx.doi.org/10.1016/s0264-410x(03)00119-1 | - |
dc.subject | CD40 ligand | - |
dc.subject | CD154 | - |
dc.subject | Respiratory syncytial virus | - |
dc.subject | Vaccination | - |
dc.subject | RSV | - |
dc.title | CD40 ligand (CD154) improves the durability of respiratory syncytial virus DNA vaccination in BALB/c mice | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/S0264-410X(03)00119-1 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Brown, M. [0000-0002-5796-1932] [0000-0002-6678-1407] | - |
Appears in Collections: | Aurora harvest 4 Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.