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Type: Journal article
Title: Anti-Müllerian hormone is not associated with cardiometabolic risk factors in adolescent females
Other Titles: Anti-Mullerian hormone is not associated with cardiometabolic risk factors in adolescent females
Author: Anderson, E.
Fraser, A.
McNally, W.
Sattar, N.
Lashen, H.
Fleming, R.
Nelson, S.
Lawlor, D.
Citation: PLoS One, 2013; 8(5):e64510-1-e64510-10
Publisher: Public Library of Science
Issue Date: 2013
ISSN: 1932-6203
Statement of
Emma L. Anderson, Abigail Fraser, William McNally, Naveed Sattar, Hany Lashen, Richard Fleming, Scott M. Nelson, Debbie A. Lawlor
Abstract: OBJECTIVES: Epidemiological evidence for associations of Anti-Müllerian hormone (AMH) with cardiometabolic risk factors is lacking. Existing evidence comes from small studies in select adult populations, and findings are conflicting. We aimed to assess whether AMH is associated with cardiometabolic risk factors in a general population of adolescent females. METHODS: AMH, fasting insulin, glucose, HDLc, LDLc, triglycerides and C-reactive protein (CRP) were measured at a mean age 15.5 years in 1,308 female participants in the Avon Longitudinal Study of Parents and Children (ALSPAC). Multivariable linear regression was used to examine associations of AMH with these cardiometabolic outcomes. RESULTS: AMH values ranged from 0.16-35.84 ng/ml and median AMH was 3.57 ng/ml (IQR: 2.41, 5.49). For females classified as post-pubertal (n = 848) at the time of assessment median (IQR) AMH was 3.81 ng/ml (2.55, 5.82) compared with 3.25 ng/ml (2.23, 5.05) in those classed as early pubertal (n = 460, P≤0.001). After adjusting for birth weight, gestational age, pubertal stage, age, ethnicity, socioeconomic position, adiposity and use of hormonal contraceptives, there were no associations with any of the cardiometabolic outcomes. For example fasting insulin changed by 0% per doubling of AMH (95%CI: -3%,+2%) p  = 0.70, with identical results if HOMA-IR was used. Results were similar after additional adjustment for smoking, physical activity and age at menarche, after exclusion of 3% of females with the highest AMH values, after excluding those that had not started menarche and after excluding those using hormonal contraceptives. CONCLUSION: Our results suggest that in healthy adolescent females, AMH is not associated with cardiometabolic risk factors.
Keywords: Cardiovascular Diseases; Risk Factors; Longitudinal Studies; Anti-Mullerian Hormone
Rights: © 2013 Anderson et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
RMID: 0030042757
DOI: 10.1371/journal.pone.0064510
Appears in Collections:Medicine publications

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