Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/98106
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Type: Journal article
Title: The effect of ginger (Zingiber officinale) on platelet aggregation: a systematic literature review
Author: Marx, W.
McKavanagh, D.
McCarthy, A.
Bird, R.
Ried, K.
Chan, A.
Isenring, L.
Citation: PLoS One, 2015; 10(10):e0141119-1-e0141119-13
Publisher: Public Library of Science
Issue Date: 2015
ISSN: 1932-6203
1932-6203
Editor: Freson, K.
Statement of
Responsibility: 
Wolfgang Marx, Daniel McKavanagh, Alexandra L. McCarthy, Robert Bird, Karin Ried, Alexandre Chan, Liz Isenring
Abstract: Background: The potential effect of ginger on platelet aggregation is a widely-cited concern both within the published literature and to clinicians; however, there has been no systematic appraisal of the evidence to date. Methods: Using the PRISMA guidelines, we systematically reviewed the results of clinical and observational trials regarding the effect of ginger on platelet aggregation in adults compared to either placebo or baseline data. Studies included in this review stipulated the independent variable was a ginger preparation or isolated ginger compound, and used measures of platelet aggregation as the primary outcome. Results: Ten studies were included, comprising eight clinical trials and two observational studies. Of the eight clinical trials, four reported that ginger reduced platelet aggregation, while the remaining four reported no effect. The two observational studies also reported mixed findings. Discussion: Many of the studies appraised for this review had moderate risks of bias. Methodology varied considerably between studies, notably the timeframe studied, dose of ginger used, and the characteristics of subjects recruited (e.g. healthy vs. patients with chronic diseases). Conclusion: The evidence that ginger affects platelet aggregation and coagulation is equivocal and further study is needed to definitively address this question.
Keywords: Humans
Ginger
Plant Extracts
Platelet Function Tests
Phytotherapy
Platelet Aggregation
Adolescent
Adult
Female
Male
Clinical Trials as Topic
Young Adult
Description: Correction: 23 Nov 2015: Marx W, McKavanagh D, McCarthy AL, Bird R, Ried K, et al. (2015) Correction: The Effect of Ginger (Zingiber officinale) on Platelet Aggregation: A Systematic Literature Review. PLoS ONE 10(11): e0143675. doi: 10.1371/journal.pone.0143675
Rights: © 2015 Marx et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
DOI: 10.1371/journal.pone.0141119
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