Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/9827
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bianco-Miotto, T. | - |
dc.contributor.author | Farmer, B. | - |
dc.contributor.author | Sage, R. | - |
dc.contributor.author | Dobrovic, A. | - |
dc.date.issued | 2001 | - |
dc.identifier.citation | Blood, 2001; 97(11):3633-3639 | - |
dc.identifier.issn | 0006-4971 | - |
dc.identifier.issn | 1528-0020 | - |
dc.identifier.uri | http://hdl.handle.net/2440/9827 | - |
dc.description | © 2001 by The American Society of Hematology | - |
dc.description.abstract | Loss of A, B, and H antigens from the surface of red blood cells has been a recurrent observation in patients with hematologic malignancy, particularly those malignancies in which the myeloid lineage is involved. To better understand this phenomenon, a 2-color flow cytometric method was developed to determine quantitative and qualitative alterations of A, B, and H antigens in patients with myeloid malignancies. Characteristic patterns, dependent on the genotype, were seen for healthy individuals from each of the blood groups. Fifty-five percent (16/29) of patients of blood group A, B, or AB had a proportion of red cells with decreased expression of A or B antigens compared with no changes in 127 healthy A, B, and AB individuals. In most cases, the changes were not detected by routine serologic typing. The loss of A or B antigens was the primary change in 28% (8/29) of patients. In 17% (5/29) of patients, loss of A or B antigens was an indirect consequence of loss of the precursor H antigen. Alterations involving both the H and the A or B antigens were seen in 10% (3/29) of patients. Loss of H was also detected in 21% (6/28) of group O patients whereas none of 51 healthy O individuals showed changes. Alterations of ABO antigens can now be considered a common event in myeloid malignancy. | - |
dc.description.statementofresponsibility | Tina Bianco, Belinda J. Farmer, Robert E. Sage, and Alexander Dobrovic | - |
dc.language.iso | en | - |
dc.publisher | Amer Soc Hematology | - |
dc.source.uri | http://bloodjournal.hematologylibrary.org/cgi/content/abstract/97/11/3633 | - |
dc.subject | Erythrocytes | - |
dc.subject | Humans | - |
dc.subject | Myelodysplastic Syndromes | - |
dc.subject | Myeloproliferative Disorders | - |
dc.subject | ABO Blood-Group System | - |
dc.subject | Flow Cytometry | - |
dc.subject | Genotype | - |
dc.subject | Adult | - |
dc.subject | Leukemia, Myeloid, Acute | - |
dc.title | Loss of red cell A, B, and H antigens is frequent in myeloid malignancies | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1182/blood.V97.11.3633 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Bianco-Miotto, T. [0000-0002-8431-5338] | - |
Appears in Collections: | Aurora harvest Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.