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Type: Journal article
Title: The association of birth order with later body mass index and blood pressure: a comparison between prospective cohort studies from the United Kingdom and Brazil
Author: Howe, L.
Hallal, P.
Matijasevich, A.
Wells, J.
Santos, I.
Barros, A.
Lawlor, D.
Victora, C.
Smith, G.
Citation: International Journal of Obesity, 2014; 38(7):973-979
Publisher: Nature Publishing Group
Issue Date: 2014
ISSN: 0307-0565
Statement of
L D Howe, P C Hallal, A Matijasevich, J C Wells, I S Santos, A J D Barros, D A Lawlor, C G Victora and G D Smith
Abstract: Previous studies have found greater adiposity and cardiovascular risk in first born children. The causality of this association is not clear. Examining the association in diverse populations may lead to improved insight.We examine the association between birth order and body mass index (BMI), systolic and diastolic blood pressure (SBP/DBP) in the 2004 Pelotas cohort from southern Brazil and the Avon Longitudinal Study of Parents and Children (ALSPAC) from Bristol, south-west England, restricting analysis to families with two children in order to remove confounding by family size.No consistent differences in BMI, SBP or DBP were observed comparing first and second born children. Within the Pelotas 2004 cohort, first born females were thinner, with lower SBP and DBP; for example, mean difference in SBP comparing first with second born was -0.979 (95% confidence interval -2.901 to 0.943). In ALSPAC, first born females had higher BMI, SBP and DBP. In both cohorts, associations tended to be in the opposite direction in males, although no statistical evidence for gender interactions was found.The findings do not support an association between birth order and BMI or blood pressure. Differences to previous studies may be explained by differences in populations and/or confounding by family size in previous studies.
Keywords: ALSPAC; birth order; blood pressure; body mass index; cardiovascular; Pelotas; siblings
Description: Published online 29 October 2013
Rights: © 2014 Macmillan Publishers Limited All rights reserved. This work is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit
RMID: 0030042759
DOI: 10.1038/ijo.2013.189
Appears in Collections:Medicine publications

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