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Type: Journal article
Title: Genome-wide association study of blood lead shows multiple associations near ALAD
Author: Warrington, N.
Zhu, G.
Dy, V.
Heath, A.
Madden, P.
Hemani, G.
Kemp, J.
Mcmahon, G.
St Pourcain, B.
Timpson, N.
Taylor, C.
Golding, J.
Lawlor, D.
Steer, C.
Montgomery, G.
Martin, N.
Smith, G.
Evans, D.
Whitfield, J.
Citation: Human Molecular Genetics, 2015; 24(13):3871-3879
Publisher: Oxford University Press
Issue Date: 2015
ISSN: 0964-6906
Statement of
Nicole M. Warrington, Gu Zhu, Veronica Dy, Andrew C. Heath, Pamela A.F. Madden, Gibran Hemani, John P. Kemp, George Mcmahon, Beate St Pourcain, Nicholas J. Timpson, Caroline M. Taylor, Jean Golding, Debbie A. Lawlor, Colin Steer, Grant W. Montgomery, Nicholas G. Martin, George Davey Smith, David M. Evans and John B. Whitfield
Abstract: Exposure to high levels of environmental lead, or biomarker evidence of high body lead content, is associated with anaemia, developmental and neurological deficits in children, and increased mortality in adults. Adverse effects of lead still occur despite substantial reduction in environmental exposure. There is genetic variation between individuals in blood lead concentration but the polymorphisms contributing to this have not been defined. We measured blood or erythrocyte lead content, and carried out genome-wide association analysis, on population-based cohorts of adult volunteers from Australia and UK (N = 5433). Samples from Australia were collected in two studies, in 1993-1996 and 2002-2005 and from UK in 1991-1992. One locus, at ALAD on chromosome 9, showed consistent association with blood lead across countries and evidence for multiple independent allelic effects. The most significant single nucleotide polymorphism (SNP), rs1805313 (P = 3.91 × 10(-14) for lead concentration in a meta-analysis of all data), is known to have effects on ALAD expression in blood cells but other SNPs affecting ALAD expression did not affect blood lead. Variants at 12 other loci, including ABO, showed suggestive associations (5 × 10(-6) > P > 5 × 10(-8)). Identification of genetic polymorphisms affecting blood lead reinforces the view that genetic factors, as well as environmental ones, are important in determining blood lead levels. The ways in which ALAD variation affects lead uptake or distribution are still to be determined.
Keywords: Adult
Description: First published online: March 27, 2015
Rights: © The Author 2015. Published by Oxford University Press. All rights reserved.
DOI: 10.1093/hmg/ddv112
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