Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/98653
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Type: Journal article
Title: Serum 25-hydroxyvitamin D₃ and D₂ and non-clinical psychotic experiences in childhood
Other Titles: Serum 25-hydroxyvitamin D(3) and D(2) and non-clinical psychotic experiences in childhood
Author: Tolppanen, A.
Sayers, A.
Fraser, W.
Lewis, G.
Zammit, S.
McGrath, J.
Lawlor, D.
Citation: PLoS One, 2012; 7(7):e41575-1-e41575-8
Publisher: Public Library of Science
Issue Date: 2012
ISSN: 1932-6203
1932-6203
Editor: Hashimoto, K.
Statement of
Responsibility: 
Anna-Maija Tolppanen, Adrian Sayers, William D. Fraser, Glyn Lewis, Stanley Zammit, John McGrath, Debbie A. Lawlor
Abstract: Non-clinical psychotic experiences are common and distressing. It has been hypothesized that early life vitamin D deficiency may be a risk factor for psychosis-related outcomes, but it is not known if circulating concentrations of 25-hydroxyvitamin D (25(OH)D) during childhood are associated with psychosis-related outcomes or whether the two different forms of 25(OH)D, (25(OH)D(3) and 25(OH)D(2), have similar associations with psychosis-related outcomes.We investigated the association between serum 25(OH)D(3) and 25(OH)D(2) concentrations and psychotic experiences in a prospective birth cohort study. Serum 25(OH)D(3) and 25(OH)D(2) concentrations were measured at mean age 9.8 years and psychotic experiences assessed at mean age 12.8 years by a psychologist (N = 3182).Higher 25(OH)D(3) concentrations were associated with lower risk of definite psychotic experiences (adjusted odds ratio: OR (95% confidence interval: CI) 0.85 (0.75-0.95)). Higher concentrations of 25(OH)D(2) were associated with higher risk of suspected and definite psychotic experiences (adjusted odds ratio: OR (95% confidence interval: CI) 1.26 (1.11, 1.43)). Higher 25(OD)D(2) concentrations were also weakly associated with definite psychotic experiences (adjusted OR (95% CI) 1.17 (0.96, 1.43), though with wide confidence intervals including the null value.Our findings of an inverse association of 25(OH)D(3) with definite psychotic experiences is consistent with the hypothesis that vitamin D may protect against psychosis-related outcomes.
Keywords: Calcifediol
25-Hydroxyvitamin D 2
Follow-Up Studies
Prospective Studies
Psychotic Disorders
Rights: © 2012 Tolppanen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI: 10.1371/journal.pone.0041575
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