Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/98653
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tolppanen, A. | - |
dc.contributor.author | Sayers, A. | - |
dc.contributor.author | Fraser, W. | - |
dc.contributor.author | Lewis, G. | - |
dc.contributor.author | Zammit, S. | - |
dc.contributor.author | McGrath, J. | - |
dc.contributor.author | Lawlor, D. | - |
dc.contributor.editor | Hashimoto, K. | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | PLoS One, 2012; 7(7):e41575-1-e41575-8 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2440/98653 | - |
dc.description.abstract | Non-clinical psychotic experiences are common and distressing. It has been hypothesized that early life vitamin D deficiency may be a risk factor for psychosis-related outcomes, but it is not known if circulating concentrations of 25-hydroxyvitamin D (25(OH)D) during childhood are associated with psychosis-related outcomes or whether the two different forms of 25(OH)D, (25(OH)D(3) and 25(OH)D(2), have similar associations with psychosis-related outcomes.We investigated the association between serum 25(OH)D(3) and 25(OH)D(2) concentrations and psychotic experiences in a prospective birth cohort study. Serum 25(OH)D(3) and 25(OH)D(2) concentrations were measured at mean age 9.8 years and psychotic experiences assessed at mean age 12.8 years by a psychologist (N = 3182).Higher 25(OH)D(3) concentrations were associated with lower risk of definite psychotic experiences (adjusted odds ratio: OR (95% confidence interval: CI) 0.85 (0.75-0.95)). Higher concentrations of 25(OH)D(2) were associated with higher risk of suspected and definite psychotic experiences (adjusted odds ratio: OR (95% confidence interval: CI) 1.26 (1.11, 1.43)). Higher 25(OD)D(2) concentrations were also weakly associated with definite psychotic experiences (adjusted OR (95% CI) 1.17 (0.96, 1.43), though with wide confidence intervals including the null value.Our findings of an inverse association of 25(OH)D(3) with definite psychotic experiences is consistent with the hypothesis that vitamin D may protect against psychosis-related outcomes. | - |
dc.description.statementofresponsibility | Anna-Maija Tolppanen, Adrian Sayers, William D. Fraser, Glyn Lewis, Stanley Zammit, John McGrath, Debbie A. Lawlor | - |
dc.language.iso | en | - |
dc.publisher | Public Library of Science | - |
dc.rights | © 2012 Tolppanen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | - |
dc.source.uri | http://dx.doi.org/10.1371/journal.pone.0041575 | - |
dc.subject | Calcifediol | - |
dc.subject | 25-Hydroxyvitamin D 2 | - |
dc.subject | Follow-Up Studies | - |
dc.subject | Prospective Studies | - |
dc.subject | Psychotic Disorders | - |
dc.title | Serum 25-hydroxyvitamin D₃ and D₂ and non-clinical psychotic experiences in childhood | - |
dc.title.alternative | Serum 25-hydroxyvitamin D(3) and D(2) and non-clinical psychotic experiences in childhood | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1371/journal.pone.0041575 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Lawlor, D. [0000-0002-6793-2262] | - |
Appears in Collections: | Aurora harvest 3 Medicine publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
hdl_98653.pdf | Published version | 527.27 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.