Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/98659
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Type: Journal article
Title: The association of 25-hydroxyvitamin D₃ and D₂ with behavioural problems in childhood
Other Titles: The association of 25-hydroxyvitamin D(3)and D(2) with behavioural problems in childhood
Author: Tolppanen, A.
Sayers, A.
Fraser, W.
Lewis, G.
Zammit, S.
Lawlor, D.
Citation: PLoS One, 2012; 7(7):e40091-e40097-8
Publisher: Public Library of Science
Issue Date: 2012
ISSN: 1932-6203
1932-6203
Editor: Laks, J.
Statement of
Responsibility: 
Anna-Maija Tolppanen, Adrian Sayers, William D. Fraser, Glyn Lewis, Stanley Zammit, Debbie A. Lawlor
Abstract: Higher serum concentrations of 25-hydroxyvitamin D (25(OH)D), an indicator of vitamin D synthesis and intake, have been associated with better mental health and cognitive function. Concentrations of 1,25-dihydroxyvitamin D(3) (the active vitamin D(3) metabolite) have been associated with openness and extrovert behaviour, but 25(OH)D concentrations have not been associated with behavioural problems in humans.We investigated the prospective association between the different forms of 25(OH)D - 25(OH)D(3) and 25(OH)D(2)- and childhood behavioural problems in Avon Longitudinal Study of Parents and Children (ALSPAC). Serum 25(OH)D(3) and 25(OH)D(2) concentrations were assessed at mean age 9.9 years. Incident behavioural problems were assessed with Strengths and Difficulties Questionnaire (SDQ; emotional symptoms, conduct problems, hyperactivity-inattention problems, peer relationship problems and pro-social behaviour subscales and total difficulties score) at mean age 11.7. Sample sizes varied between 2413-2666 depending on the outcome.Higher 25(OH)D(3) concentrations were weakly associated with lower risk of prosocial problems (fully adjusted odds ratio: OR (95% confidence interval: CI) 0.85 (0.74, 0.98)). Serum 25(OH)D(3) or 25(OH)D(2) concentrations were not associated with other subscales of SDQ or total difficulties score after adjusting for concfounders and other measured analytes related to vitamin D.Our findings do not support the hypothesis that 25-hydroxyvitamin D status in childhood has important influences on behavioural traits in humans.
Keywords: Calcifediol
25-Hydroxyvitamin D 2
Child Behavior Disorders
Confounding Factors (Epidemiology)
Rights: © 2012 Tolppanen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI: 10.1371/journal.pone.0040097
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