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Type: Journal article
Title: Effects of intraarticular ropivacaine and morphine on lipopolysaccharide-induced synovitis in horses
Author: Santos, L.C.P.
de Moraes, A.N.
Saito, M.E.
Citation: Veterinary Anaesthesia and Analgesia, 2009; 36(3):280-286
Publisher: Wiley
Issue Date: 2009
ISSN: 1467-2987
Statement of
Luiz César Pereira Santos, Aury Nunes De Moraes and Mere Erika Saito
Abstract: Objective:  To compare the intraarticular (IA) analgesic effects of ropivacaine and morphine in horses with experimentally induced synovitis. Study design:  Randomized, blinded cross-over design. Animals:  Twelve healthy mixed breed horses between 8–15 years old. Methods:  Synovitis was induced in the left radio-carpal joint with an injection of lipopolysaccharide (Escherichia coli 055:B5). Six hours later, the horses were treated with an IA injection of 40 mg of ropivacaine (ROPI), 40 mg of morphine (MOR), 20 mg of ropivacaine added to 20 mg of morphine in saline (RM) or 4 mL of saline (SAL), as control. Analgesia was measured subjectively using a numerical rating scale, a simple descriptive scale, pain upon maximal flexion of the carpus and by the range of motion exhibited by the affected joint. Data are reported as mean ± SD and were analyzed using anova. Blood and synovial data were analyzed by split plots in time with units (treatments: SAL, ROPI, MOR and RM) and subunits (times: T0–24), in a completely randomized design with six replicates. Mean comparisons were made by Tukey’s test; differences were considered significant at p < 0.05. Results:  Ropivacaine had a clinical analgesic effect with a relative short duration (∼2.5 to 3.5 hours). Morphine had a slower onset of action than ROPI, but a stronger analgesic effect of longer duration. The RM showed an earlier onset of action than MOR and had a strong analgesic effect for the 24-hour post-injection period. All treatments caused a significant decrease in total nucleated cells compared with the control, 24 hours after administration. Conclusions and clinical relevance:  Morphine alone or in combination with ropivacaine produced a strong analgesic effect of prolonged duration, which may offer pain relief for acute synovitis for at least 24 hours.
Keywords: analgesia; equine; intraarticular; morphine; ropivacaine; synovitis
Rights: © 2009 The Authors. Journal compilation © 2009 Association of Veterinary Anaesthetists
DOI: 10.1111/j.1467-2995.2009.00452.x
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Appears in Collections:Animal and Veterinary Sciences publications
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