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https://hdl.handle.net/2440/9880
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Type: | Journal article |
Title: | Formoterol in patients with chronic obstructive pulmonary disease: a randomized, controlled, 3-month trial |
Author: | Aalbers, R. Ayres, J. Backer, V. Decramer, M. Lier, P. Magyar, P. Malolepszy, J. Ruffin, R. Sybrecht, G. |
Citation: | European Respiratory Journal, 2002; 19(5):936-943 |
Publisher: | Munksgaard Int Publ Ltd |
Issue Date: | 2002 |
ISSN: | 0903-1936 1399-3003 |
Statement of Responsibility: | R. Aalbers, J. Ayres, V. Backer, M. Decramer, P.A. Lier, P. Magyar, J. Malolepszy, R. Ruffin and G.W. Sybrecht |
Abstract: | The aim of this study was to investigate formoterol, an inhaled longacting b2-agonist, in patients with chronic obstructive pulmonary disease (COPD). Six-hundred and ninety-two COPD patients, mean baseline forced expiratory volume in one second (FEV1) 54%, FEV1/forced vital capacity 75% of predicted, reversibility 6.4% pred, were treated with formoterol (4.5, 9 or 18 mg b.i.d.) or placebo via Turbuhaler1 for 12 weeks. Symptoms were recorded daily. Spirometry and the incremental shuttle walking test (SWT) were performed at clinic visits. Compared with placebo, 18 mg b.i.d. formoterol reduced the mean total symptom score by 13% and increased the percentage of nights without awakenings by 15%. Formoterol (9 and 18 mg b.i.d.) significantly reduced symptom scores for breathlessness (-7% and -9%, respectively) and chest tightness (-11% and -8%, respectively), reduced the need for rescue medication (-25% and -18%, respectively), and increased symptomfree days (71% and 86%, respectively). FEV1 improved significantly after all three doses of formoterol (versus placebo). No differences were found between groups in SWT walking distance. No unexpected adverse events were seen. In conclusion, 9 and 18 mg b.i.d. formoterol reduced symptoms and increased the number of symptom-free days in a dose-dependent manner in chronic obstructive pulmonary disease patients. Formoterol improved lung function at a dose of 4.5 mg b.i.d. and higher. |
Keywords: | Humans Pulmonary Disease, Chronic Obstructive Ethanolamines Bronchodilator Agents Exercise Test Diagnostic Techniques, Respiratory System Spirometry Treatment Outcome Administration, Inhalation Severity of Illness Index Double-Blind Method Time Factors Aged Middle Aged Female Male Formoterol Fumarate |
Rights: | Copyright ©ERS Journals Ltd 2002 |
DOI: | 10.1183/09031936.02.00240902 |
Published version: | http://dx.doi.org/10.1183/09031936.02.00240902 |
Appears in Collections: | Aurora harvest Medicine publications |
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