Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/98873
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Type: Journal article
Title: Comparative effects of intraduodenal protein and lipid on ghrelin, peptide YY, and leptin release in healthy men
Author: Ullrich, S.
Otto, B.
Hutchison, A.
Luscombe-Marsh, N.
Horowitz, M.
Feinle-Bisset, C.
Citation: American Journal of Physiology, 2015; 308(4):R300-R304
Publisher: American Physiological Society
Issue Date: 2015
ISSN: 0363-6119
1522-1490
Statement of
Responsibility: 
Sina S. Ullrich, Bärbel Otto, Amy T. Hutchison, Natalie D. Luscombe-Marsh, Michael Horowitz, Christine Feinle-Bisset
Abstract: Intraduodenal infusion of lipid or protein potently reduces subsequent energy intake. There is evidence that the underlying mechanisms differ significantly between the two nutrients. While intraduodenal lipid stimulates glucagon-like peptide-1 and CCK much more than protein, the release of insulin and glucagon is substantially greater in response to protein. Ghrelin and PYY are both involved in short-term regulation, while leptin is a long-term regulator, of energy balance; the acute effects of nutrients on leptin release are unclear. We investigated the comparative effects of intraduodenal lipid and protein on plasma ghrelin, PYY, and leptin concentrations. Thirteen lean, young men received 90-min intraduodenal infusions of protein (whey hydrolysate) or lipid (long-chain triglyceride emulsion) at a rate of 3 kcal/min, or saline control, on three separate days. Blood samples were collected at baseline and regularly during infusions. Both lipid and protein potently suppressed plasma ghrelin compared with control (both P < 0.001), with no difference between them. While both lipid and protein stimulated plasma PYY (P < 0.001), the effect of lipid was substantially greater than that of protein (P < 0.001). Neither intraduodenal lipid nor protein affected plasma leptin. In conclusion, intraduodenal lipid and protein have discrepant effects on the release of PYY, but not ghrelin. When considered with our previous findings, it appears that, with the exception of ghrelin, the energy intake-suppressant effects of lipid and protein are mediated by different mechanisms.
Keywords: Gut hormones; Humans; Gastrointestinal function; Food intake
Rights: © 2015 the American Physiological Society
RMID: 0030018734
DOI: 10.1152/ajpregu.00504.2014
Grant ID: http://purl.org/au-research/grants/nhmrc/627118
http://purl.org/au-research/grants/nhmrc/627002
http://purl.org/au-research/grants/nhmrc/565312
Appears in Collections:Medicine publications

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