Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/9892
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Type: Journal article
Title: Failed reperfusion after thrombolytic therapy: Recognition and management
Author: Kucia, A.
Zeitz, C.
Citation: Heart & Lung, 2002; 31(2):113-121
Publisher: Mosby Inc
Issue Date: 2002
ISSN: 0147-9563
1527-3288
Statement of
Responsibility: 
Angela Marie Kucia and Christopher James [sic] Zeitz
Abstract: Background: Failed reperfusion after thrombolysis occurs in as many as 30% of patients with acute myocardial infarction (MI). Furthermore, some patients have incomplete tissue perfusion despite reperfusion of the infarct-related artery. Close assessment of the efficacy of thrombolytic administration in people with evolving acute MI is necessary, particularly with regard to myocardial perfusion status, because some patients may benefit from incremental pharmacologic or invasive reperfusion strategies. Purpose and Method: This article reviews a number of strategies to assess infarct-related artery patency and myocardial tissue perfusion. These include coronary angiography, continuous ST-segment monitoring, serial electrocardiography, obtaining serial serum biochemical markers of myocardial necrosis, monitoring for reperfusion arrhythmias, and assessment of changes in chest pain intensity. Conclusion: The early detection of failed reperfusion is critical if incremental strategies to enhance myocardial salvage are to be considered. Continuous ST-segment monitoring is a relatively inexpensive, reliable, and accurate tool for assessing real-time myocardial perfusion. (Heart Lung® 2002;31:113-21.)
Keywords: Humans; Myocardial Infarction; Fibrinolytic Agents; Coronary Angiography; Electrocardiography; Treatment Failure; Emergency Treatment; Myocardial Reperfusion; Severity of Illness Index; Risk Assessment; Risk Factors; Follow-Up Studies; Vascular Patency; Female; Male; Angioplasty, Balloon, Coronary
Description: © 2002 Mosby, Inc. All rights reserved.
RMID: 0020021368
DOI: 10.1067/mhl.2002.122649
Description (link): http://www.elsevier.com/wps/find/journaldescription.cws_home/623089/description#description
Appears in Collections:Medicine publications

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