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Type: Thesis
Title: Variability of nitric oxide signalling in atrial fibrillation: potential modulation.
Author: Procter, Nathan Edward Kevin
Issue Date: 2015
School/Discipline: School of Medicine
Abstract: Understanding of the biochemical bases of thromboembolic risk in atrial fibrillation (AF) is incomplete. In a cohort of AF patients admitted to hospital, integrity of platelet nitric oxide (NO) signalling, and its modulation by dimethylarginines, myeloperoxidase, thrombospondin-1and thioredoxin-interacting protein, was investigated. This study identified that, (1) new onset AF is associated with impaired platelet NO response; (2) gender-specific platelet dysfunction exists in AF where females display increased platelet aggregability and impaired NO response compared to males; (3) plasma symmetric dimethylarginine correlated inversely with platelet aggregability in chronic AF patients. Abnormalities of NO signalling and its various determinants occur frequently in AF patients at risk of thromboembolism.
Advisor: Horowitz, John David
Chirkov, Yuliy
Dissertation Note: Thesis (Ph.D.) -- University of Adelaide, School of Medicine, 2015
Keywords: Atrial fibrillation; platelet; aggregation; nitric oxide; asymmetric dimethylarginine; myeloperoxidase; thrombospondin-1; thioredoxin-interacting protein
Provenance: This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exceptions. If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at:
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