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Type: Journal article
Title: Dosage sensitivity of RPL9 and concerted evolution of ribosomal protein genes in plants
Author: Devis, D.
Firth, S.
Liang, Z.
Byrne, M.
Citation: Frontiers in Plant Science, 2015; 6(DEC):1102-1-1102-12
Publisher: Frontiers Media
Issue Date: 2015
ISSN: 1664-462X
Statement of
Deborah Devis, Sue M. Firth, Zhe Liang and Mary E. Byrne
Abstract: The ribosome in higher eukaryotes is a large macromolecular complex composed of four rRNAs and eighty different ribosomal proteins. In plants, each ribosomal protein is encoded by multiple genes. Duplicate genes within a family are often necessary to provide a threshold dose of a ribosomal protein but in some instances appear to have non-redundant functions. Here, we addressed whether divergent members of the RPL9 gene family are dosage sensitive or whether these genes have non-overlapping functions. The RPL9 family in Arabidopsis thaliana comprises two nearly identical members, RPL9B and RPL9C, and a more divergent member, RPL9D. Mutations in RPL9C and RPL9D genes lead to delayed growth early in development, and loss of both genes is embryo lethal, indicating that these are dosage-sensitive and redundant genes. Phylogenetic analysis of RPL9 as well as RPL4, RPL5, RPL27a, RPL36a, and RPS6 family genes in the Brassicaceae indicated that multicopy ribosomal protein genes have been largely retained following whole genome duplication. However, these gene families also show instances of tandem duplication, small scale deletion, and evidence of gene conversion. Furthermore, phylogenetic analysis of RPL9 genes in angiosperm species showed that genes within a species are more closely related to each other than to RPL9 genes in other species, suggesting ribosomal protein genes undergo convergent evolution. Our analysis indicates that ribosomal protein gene retention following whole genome duplication contributes to the number of genes in a family. However, small scale rearrangements influence copy number and likely drive concerted evolution of these dosage-sensitive genes.
Keywords: Concerted evolution; Dosage sensitive; Gene redundancy; Plant; Ribosomal protein
Rights: © 2015 Devis, Firth, Liang and Byrne. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
RMID: 0030046175
DOI: 10.3389/fpls.2015.01102
Grant ID:
Appears in Collections:Agriculture, Food and Wine publications

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