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dc.contributor.authorEllis, G.-
dc.contributor.authorAnderson, R.-
dc.contributor.authorChirkov, Y.-
dc.contributor.authorMorris-Thurgood, J.-
dc.contributor.authorJackson, S.-
dc.contributor.authorLewis, M.-
dc.contributor.authorHorowitz, J.-
dc.contributor.authorFrenneaux, M.-
dc.identifier.citationJournal of Cardiovascular Pharmacology, 2001; 37(5):564-570-
dc.description© 2001 Lippincott Williams & Wilkins, Inc., Philadelphia-
dc.description.abstractChronic heart failure (CHF) is characterized by a prothrombotic state, which may relate to increased platelet aggregability, endothelial dysfunction, and increased oxidative stress. We investigated the effect of vitamin C in CHF on ex vivo platelet aggregation and platelet responsiveness to the anti-aggregatory effects of the nitric oxide (NO) donors glyceryl trinitrate (GTN) and sodium nitroprusside (SNP). We also examined parameters of oxidative stress and endothelial function in patients. In this double-blind, randomized, crossover study vitamin C (2 g) or placebo was given intravenously to 10 patients with CHF. We measured adenosine 5-diphosphate (ADP)-induced platelet aggregation, flow-mediated dilatation (FMD) in the brachial artery using ultrasonic wall-tracking, and plasma levels of lipid-derived free radicals using electron paramagnetic resonance spectroscopy. Vitamin C did not affect ex vivo platelet aggregability but enhanced the inhibition of platelet aggregation by SNP (62.7+/-10.2 to 82.7+/-4.8%, p = 0.03) and tended to increase responses to GTN (40.5+/-9.0 to 53.4+/-7.3, p = 0.06). The effect of vitamin C on platelet responsiveness to the antiaggregatory effects of SNP was inversely related to basal response to SNP (r = -0.9, p < 0.01); a similar trend was observed with GTN (r = -0.6, p = 0.1). Vitamin C also increased FMD (1.9+/-0.6 to 5.8+/-1.5%, p = 0.02) and reduced plasma lipid-derived free radicals by 49+/-19% (p < 0.05). In patients with CHF acute intravenous administration of vitamin C enhances platelet responsiveness to the anti-aggregatory effects of NO donors and improves endothelial function, suggesting a potential role for vitamin C as a therapeutic agent in CHF.-
dc.description.statementofresponsibilityGethin R. Ellis, Richard A. Anderson, Yuliy Y. Chirkov, Jayne Morris-Thurgood, Simon K. Jackson, Malcolm J. Lewis, John D. Horowitz, and Michael P. Frenneaux-
dc.publisherLippincott Williams & Wilkins-
dc.subjectEndothelium, Vascular-
dc.subjectChronic Disease-
dc.subjectAscorbic Acid-
dc.subjectNitric Oxide Donors-
dc.subjectVasodilator Agents-
dc.subjectAnalysis of Variance-
dc.subjectLinear Models-
dc.subjectCross-Over Studies-
dc.subjectDouble-Blind Method-
dc.subjectOxidative Stress-
dc.subjectPlatelet Aggregation-
dc.subjectMiddle Aged-
dc.subjectHeart Failure-
dc.titleAcute effects of vitamin c on platelet responsiveness to nitric oxide donors and endothelial function in patients with chronic heart failure-
dc.typeJournal article-
dc.identifier.orcidHorowitz, J. [0000-0001-6883-0703]-
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